It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Context
The study of gonadal hormone effects on adolescent wellbeing has been limited by logistical challenges. Urine hormone profiling offers new opportunities to understand the health and behavioral implications of puberty hormones.
Objective
To characterize pubertal change in urinary testosterone and estradiol among male and female adolescents, respectively.
Design
Three-year prospective cohort study.
Setting
Australian regional community.
Participants
282 (163 male) normally developing adolescents aged 11.8 ± 1.0 years at baseline.
Main outcome measure
Quarterly urine measurements of testosterone and estradiol (mass spectrometry); annual anthropometric assessment and Tanner stage (TS) self-report.
Results
Two-class sigmoidal and quadratic growth mixture models (centered on age at TS3) were identified as best-fit for describing testosterone (male) and estradiol (female) change. Classes 1 (male: 63%; female: 82%) and 2 (male: 37%; female: 18%) were respectively named the “stable” and “unstable” trajectories, characterized by different standard deviation of quarterly hormone change and magnitude of hormone peaks and troughs (all P < 0.001). Compared with class 1 (stable), class 2 males were taller at baseline (154 vs 151 cm), reported earlier and faster TS progression (P < 0.01), and showed higher serum testosterone levels at baseline and 3 years (P ≤ 0.01). Class 2 females exhibited smaller height and weight gains over the 3 years and had higher baseline serum estradiol (249 vs 98 pmol/L; P = 0.002) than class 1.
Conclusions
Adolescents showed 2 distinct urinary gonadal hormone trajectories, characterized by stability of change over time, which were not associated with consistent anthropometric differences. Results provide a methodology for studying gonadal hormone impacts on other aspects of biopsychosocial wellbeing. Identification of potential “at-risk” hormone groups would be important for planning supportive interventions.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 The University of Sydney, Faculty of Medicine and Health, Sydney Medical School, Discipline of Child and Adolescent Health, Westmead, NSW, Australia; The Children’s Hospital at Westmead, Academic Department of Adolescent Medicine, Westmead, NSW, Australia
2 University of New South Wales, South Western Sydney Clinical School, Liverpool, NSW, Australia; Ingham Institute for Applied Medical Research, Respiratory Medicine Research Stream, Liverpool, NSW, Australia
3 The University of Sydney, Faculty of Medicine and Health, School of Rural Health, Orange, NSW, Australia
4 The University of Sydney, ANZAC Research Institute, Concord, NSW, Australia