Abstract

Malignant peritoneal mesothelioma is a rare cancer originating primarily from the peritoneum with a poor prognosis and non-specific clinical presentation. We present a case of a 60-year-old male, retired metallurgy engineer who initially presented with shortness of breath, lethargy, weight loss, vague abdominal pain and night sweats. Extensive workup for almost 2 months finally leads to the diagnosis of primary malignant peritoneal mesothelioma based on immunohistochemical analysis of loss of BAP1 gene. The patient was deemed non-suitable for surgical management and started on palliative carboplatin and pemetrexed. In conclusion, histological diagnosis is essential for peritoneal diseases before considering it as a metastasis from other primary tumours. Furthermore, immunohistochemical analysis and genetic profiling may also guide towards the diagnosis and possible treatment.

Details

Title
Malignant peritoneal mesothelioma—a diagnostic challenge
Author
Saad Abdul Razzak 1   VIAFID ORCID Logo  ; Awan, Faisal 2 ; Salman, Ahmed 1 

 General Surgery Department, St. Luke’s General Hospital , Kilkenny , Ireland 
 St Luke’s General Hospital , Kilkenny , Ireland 
Publication year
2022
Publication date
Dec 2022
Publisher
Oxford University Press
e-ISSN
20428812
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3170758652
Copyright
Published by Oxford University Press and JSCR Publishing Ltd. © The Author(s) 2022. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.