Details
Title
Functional genomics pipeline identifies CRL4 inhibition for the treatment of ovarian cancer
Author
Claridge, Sally E. 1
; Nath, Shalini 2 ; Baum, Anneliese 3 ; Farias, Richard 3 ; Cavallo, Julie‐Ann 3 ; Rizvi, Nile M. 3 ; De Boni, Lamberto 1 ; Park, Eric 3 ; Granados, Genesis Lara 3 ; Hauesgen, Matthew 3 ; Fernandez‐Rodriguez, Ruben 4 ; Kozan, Eda Nur 5 ; Kanshin, Evgeny 6 ; Huynh, Khoi Q. 7 ; Chen, Peng‐Jen 7 ; Wu, Kenneth 8 ; Ueberheide, Beatrix 9 ; Mosquera, Juan Miguel 5 ; Hirsch, Fred R. 10 ; DeVita, Robert J. 11 ; Elemento, Olivier 12 ; Pauli, Chantal 13 ; Pan, Zhen‐Qiang 14 ; Hopkins, Benjamin D. 2
1 Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA, Englander Institute for Precision Medicine, Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA, Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
2 Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA, Englander Institute for Precision Medicine, Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA
3 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA, Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
4 Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
5 Englander Institute for Precision Medicine, Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA
6 Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA, Proteomics Laboratory, New York University School of Medicine, New York, New York, USA
7 Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA, Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
8 Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
9 Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA, Proteomics Laboratory, New York University School of Medicine, New York, New York, USA, Department of Neurology, New York University Grossman School of Medicine, New York, New York, USA
10 Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA, Department of Medicine, Hematology, and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, USA, Department of Pathology, Molecular and Cell‐Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
11 Proteomics Laboratory, New York University School of Medicine, New York, New York, USA, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
12 Englander Institute for Precision Medicine, Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, New York, USA, Clinical and Translational Science Center, Weill Cornell Medicine, New York, New York, USA
13 Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland
14 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
; Nath, Shalini 2 ; Baum, Anneliese 3 ; Farias, Richard 3 ; Cavallo, Julie‐Ann 3 ; Rizvi, Nile M. 3 ; De Boni, Lamberto 1 ; Park, Eric 3 ; Granados, Genesis Lara 3 ; Hauesgen, Matthew 3 ; Fernandez‐Rodriguez, Ruben 4 ; Kozan, Eda Nur 5 ; Kanshin, Evgeny 6 ; Huynh, Khoi Q. 7 ; Chen, Peng‐Jen 7 ; Wu, Kenneth 8 ; Ueberheide, Beatrix 9 ; Mosquera, Juan Miguel 5 ; Hirsch, Fred R. 10 ; DeVita, Robert J. 11 ; Elemento, Olivier 12 ; Pauli, Chantal 13 ; Pan, Zhen‐Qiang 14 ; Hopkins, Benjamin D. 2 1 Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA, Englander Institute for Precision Medicine, Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA, Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
2 Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA, Englander Institute for Precision Medicine, Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA
3 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA, Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
4 Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
5 Englander Institute for Precision Medicine, Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA
6 Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA, Proteomics Laboratory, New York University School of Medicine, New York, New York, USA
7 Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA, Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
8 Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
9 Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA, Proteomics Laboratory, New York University School of Medicine, New York, New York, USA, Department of Neurology, New York University Grossman School of Medicine, New York, New York, USA
10 Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA, Department of Medicine, Hematology, and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, USA, Department of Pathology, Molecular and Cell‐Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
11 Proteomics Laboratory, New York University School of Medicine, New York, New York, USA, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
12 Englander Institute for Precision Medicine, Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, New York, USA, Clinical and Translational Science Center, Weill Cornell Medicine, New York, New York, USA
13 Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland
14 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Section
RESEARCH ARTICLE
Publication year
2025
Publication date
Feb 1, 2025
e-ISSN
20011326
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3170826138
Copyright
© 2025. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.