Abstract

We report Babesia microti genomic sequences with multiple mutations in the atovaquone-target region of cytochrome b, including a newly identified Y272S mutation, plus 1 mutation of undetermined significance in the azithromycin-associated ribosomal protein L4. The parasite was sequenced from an immunocompromised patient on prophylactic atovaquone for Pneumocystis pneumonia before diagnosis of babesiosis.

Details

Title
Babesia microti Variant With Multiple Resistance Mutations Detected in an Immunocompromised Patient Receiving Atovaquone Prophylaxis
Author
Holbrook, Nolan R 1   VIAFID ORCID Logo  ; Klontz, Erik H 1 ; Adams, Gordon C 2 ; Schnittman, Samuel R 3 ; Issa, Nicolas C 3 ; Bond, Sheila A 3 ; Branda, John A 1 ; Lemieux, Jacob E 2 

1  Department of Pathology, Massachusetts General Hospital , Boston, Massachusetts , USA 
2  Infectious Diseases Division, Massachusetts General Hospital , Boston, Massachusetts , USA 
3  Division of Infectious Diseases, Brigham and Women’s Hospital , Boston, Massachusetts , USA 
Publication year
2023
Publication date
Mar 2023
Publisher
Oxford University Press
e-ISSN
23288957
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1093/ofid/ofad097
ProQuest document ID
3170920984
Copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.