Abstract

Talaromyces marneffei causes fatal invasive mycosis in Southeast Asia. Diagnosis by culture has limited sensitivity and can result in treatment delay. We describe the use of a novel Mp1p enzyme immunoassay (EIA) to identify blood culture–negative talaromycosis, subsequently confirmed by bone marrow cultures. This EIA has the potential to speed diagnosis, enabling early therapy initiation.

Details

Title
Occult Talaromyces marneffei Infection Unveiled by the Novel Mp1p Antigen Detection Assay
Author
Ly, Vo Trieu 1 ; Nguyen, Tat Thanh 2 ; Nguyen Thi Mai Thu 3 ; Chan, Jasper 4   VIAFID ORCID Logo  ; Day, Jeremy N 5   VIAFID ORCID Logo  ; Perfect, John 6 ; Cao, Ngoc Nga 7 ; Nguyen Van Vinh Chau 8 ; Le, Thuy 3 

1  University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam 
2  Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam 
3  Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Division of Infectious Diseases and International Health, Duke University School of Medicine, Durham, North Carolina, USA 
4  State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong; Hainan Medical University–The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University, Haikou, Hainan, China 
5  Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Center for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK 
6  Division of Infectious Diseases and International Health, Duke University School of Medicine, Durham, North Carolina, USA 
7  University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam 
8  Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam 
Publication year
2020
Publication date
Nov 2020
Publisher
Oxford University Press
e-ISSN
23288957
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1093/ofid/ofaa502
ProQuest document ID
3170967111
Copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.