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Abstract
In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMP-SMX. Development of resistance further limits the use of TMP-SMX in CRE infections.
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Details
1 Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina
2 Department of Infectious Diseases, Cleveland Clinic, Cleveland, Ohio
3 Department of Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio
4 Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio
5 Department of Medicine, MetroHealth Medical Center, Cleveland, Ohio
6 Department of Internal Medicine, Northeast Ohio Medical University, Rootstown, Ohio; Division of Infectious Diseases, Akron General Medical Center, Akron, Ohio
7 Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio; Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio
8 Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
9 Division of Infectious Diseases, University of Michigan, Ann Arbor, Michigan
10 The Biostatistics Center, The George Washington University, Rockville, Maryland
11 Division of Infectious Diseases, Duke University, Durham, North Carolina; Duke Clinical Research Institute, Duke University, Durham, North Carolina
12 Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio; Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio; Departments of Pharmacology, Molecular Biology and Microbiology, Biochemistry, and Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio
13 Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina; Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina