Abstract

We evaluated the impact of on-demand oral tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) for pre-exposure prophylaxis (PrEP) on herpes simplex virus (HSV)-1/2 incidence among men who have sex with men (MSM) enrolled in the ANRS IPERGAY trial. Serum samples were tested at baseline and at the last visit for HSV-1/2 antibodies. Overall HSV-1 incidence was 11.7 per 100 person-years; 16.2 and 7.8 per 100 person-years in the TDF/FTC and placebo arm, respectively (P = .19). Overall HSV-2 incidence was 7.6 per 100 person-years; 8.1 and 7.0 per 100 person-years in the TDF/FTC and placebo arm, respectively (P = .75). On-demand oral PrEP with TDF/FTC failed to reduce HSV-1/2 incidence in this population.

Details

Title
Effect of On-Demand Oral Pre-exposure Prophylaxis With Tenofovir/Emtricitabine on Herpes Simplex Virus-1/2 Incidence Among Men Who Have Sex With Men: A Substudy of the ANRS IPERGAY Trial
Author
Chaix, Marie-Laure 1 ; Charreau, Isabelle 2 ; Pintado, Claire 3 ; Delaugerre, Constance 1 ; Mahjoub, Nadia 4 ; Cotte, Laurent 5 ; Capitant, Catherine 2 ; Raffi, François 6 ; Cua, Eric 7 ; Pialoux, Gilles 8 ; Tremblay, Cécile 9 ; Meyer, Laurence 10 ; Molina, Jean-Michel 11 ; Pintado, C; Loze, B; Delaugerre, C; Charbonneau, P; Gatey, C; Ponscarme, D; Penot, P; Niedbalski, L; Veron, R; Delgado, J; Dalle, E; Parlier, S; Madelaine, I; Fonsart, J; Danet, M; Mahjoub, N; Mezreb, N; Moudachirou, K; Morel, S; Conort, G; Lorho, F; Meunier, M; Rozenbaum, W; Molina, J M; Chas, J; Monfort, C; Foucoin, J; Boissavy, B; Cousseau, S; Huon, S; Djessima, A; Berrebi, V; Adda, A; S le Nagat; Zarka, L; Berdougo, J; Pialoux, G; Chidiac, C; Mzoughi, N; Clement, F; Decouty, A; Chapolard, C; Godinot, M; Adouard-groslafeige, C; Koffi, J; Pansu, A; Becker, A; Pailhes, S; Bonnet, F; Jeanblanc, F; Brochier, C; Teruin, X; Rouby, S; Gilly, L; Cotte, L; Etienne, C; Tolonin, F; Breaud, S; Péchenot, V; Bagge, S; Cepitelli, T; Roger, P M; Rosenthal, E; Cua, E; Cheret, A; Cornavin, P; Vandamme, S; Lambec, J; Dumon, N; Leclanche, O; Huleux, T; Biekre, R; Robineau, O; Melliez, H; Bazus, H; Pasquet, A; Bernaud, C; Besnier, M; Bonnet, B; Hall, N; Cavellec, M; Hue, H; Larmet, L; Colas, M; Choquet, R; Raffi, F; Beauvais, C; Arlotto, P; Fortin, C; Talbot, A; Chamberland, A; McKenzie, A; Blanchette, M; Rousseau, R; Montheuth, K; Otis, J; Thompson, D; Morin, M; Wainberg, M; Tremblay, C; Meyer, L; Capitant, C; Charreau, I; Guillon, B; Netzer, E; Leturque, N; Binesse, J; Foubert, V; Saouzanet, M; Euphrasie, F; Carette, D; Aboulker, J P; Spire, B; Sagaon-Teyssier, L; Suzan, M; Fressard, L; Demoulin, B; Cattin, G; Lorente, N; Doré, V; Marchand, L; S Le Mestre; Mennecier, A; Choucair, E; Etien, N; Diallo, A; Gibowski, S; M-C, Simon; J-F Delfraissy; Le Gall, J M; Pechenot, V; Taba, A Djessima; B Dos Santos; Coquelin, V; Brunet, P; Porion, R; D Rojas Castro; Wainberg, Mark; Trottier, Benoit; Baril, Jean-Guy; Chéret, Antoine; Pasquet, Armelle; Besnier, Michel; Rozenbaum, Willy; Chidiac, Christian; Bajos, Nathalie; Timsit, Julie; Peytavin, Gilles; Fonsart, Julien; Durand-Zaleski, Isabelle; Aboulker, Jean-Pierre; Spire, Bruno; Suzan-Monti, Marie; Girard, Gabriel; Daniela Rojas Castro; Préau, Marie; Morin, Michel; Thompson, David; Marchand, Lucie; Doré, Véronique; Simon, Marie-Christine; Otis, Joanne; Lert, France; Diallo, Alpha; Gibowski, Séverine; Rabian, Cecile

1  Virologie, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité, Centre National de la Recherche Scientifique Unité Mixte de Recherche, Institut Universitaire d’Hématologie, Sorbonne Paris Cité, Université Paris Diderot, Hôpital Saint Louis, France 
2  INSERM Service Commun, Villejuif, France 
3  Maladies Infectieuses, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris, France 
4  Virologie, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris, France 
5  Maladies Infectieuses, Hôpital de la Croix Rousse, Centre Hospitalier et Universitaire de Lyon, France 
6  Department of Infectious Diseases, University Hospital of Nantes and Centre d’Investigation Clinique, INSERM, Nantes 
7  Maladies Infectieuses, Hôpital de l’Archet, Centre Hospitalier de Nice, France 
8  Maladies Infectieuses, Hôpital Tenon, Assistance Publique Hôpitaux de Paris, France 
9  Maladies Infectieuses, Centre Hospitalier de l’Université de Montréal, Canada 
10  INSERM Service Commun, Villejuif, France; Université Paris-Sud, Université Paris-Saclay, France 
11  Institut National de la Santé et de la Recherche Médicale (INSERM) Unité, Centre National de la Recherche Scientifique Unité Mixte de Recherche, Institut Universitaire d’Hématologie, Sorbonne Paris Cité, Université Paris Diderot, Hôpital Saint Louis, France; Maladies Infectieuses, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris, France 
Publication year
2018
Publication date
Nov 2018
Publisher
Oxford University Press
e-ISSN
23288957
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1093/ofid/ofy295
ProQuest document ID
3170976527
Copyright
© The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.