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© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

This study evaluates the wound-healing process in horses following the application of two treatment modalities: bacterial cellulose hydrogel with alginate (BCAW) and frog skin (FSW) dressings on experimentally induced skin wounds. Throughout the experiment, no clinical abnormalities were noted in the horses, although initial wound assessments indicated edema and sensitivity. Local hemorrhage was observed in some cases on Day 0, with granulation tissue formation evident by Day 14. Epithelialization began around Day 14 but did not reach complete healing in any group by Day 28. The analysis showed no significant differences in skin wound area or wound contraction rates among the treatment groups compared to control wounds (CWs) over the evaluation periods. Histopathological evaluations also indicated no significant differences in inflammatory responses or healing markers, such as fibroblast proliferation and neovascularization in skin wounds across groups. Despite expectations based on prior research in other species, the treatments with BCAW and FSW did not demonstrate substantial pro-healing effects in horses with induced skin wounds. These findings underscore the complexity of equine wound healing and suggest further investigation is needed to optimize treatment strategies in this species and enhance the translational potential for human clinical applications.

Details

Title
Evaluation of Bacterial Cellulose/Alginate-Based Hydrogel and Frog Skin Dressings in Equine Skin Wound Healing
Author
Campebell, Rita C 1   VIAFID ORCID Logo  ; Oliveira, Andressa B 1 ; Fagundes, Jéssyca L A 1 ; Fortes, Beatriz N A 1 ; Veado, Henrique C 1   VIAFID ORCID Logo  ; Macedo, Isabel L 1   VIAFID ORCID Logo  ; Dallago, Bruno S L 1   VIAFID ORCID Logo  ; Barud, Hernane S 2 ; Adorno, José 3 ; Salvador, Pablo A V 4   VIAFID ORCID Logo  ; Santos, Paulo S 4 ; Castro, Márcio B 1   VIAFID ORCID Logo 

 Hospital Escola de Grandes Animais, Faculdade de Agronomia e Medicina Veterinária (FAV), Universidade de Brasília (UnB), Área Especial SRB, Galpão 4, Granja do Torto 70636-200, DF, Brazil; [email protected] (A.B.O.); [email protected] (J.L.A.F.); [email protected] (B.N.A.F.); [email protected] (H.C.V.); [email protected] (I.L.M.); [email protected] (B.S.L.D.); [email protected] (M.B.C.) 
 Laboratório de Biopolímeros e Biomateriais (BIOPOLMAT), Departamento de Química, Universidade de Araraquara (UNIARA), Araraquara 14800-000, SP, Brazil; [email protected] 
 Asa Norte Regional Hospital, HRAN, SMHN Q2, Asa Norte, Brasília 70710-100, DF, Brazil; [email protected] 
 Radiation Technology Center, CETER-IPEN-CNEN/SP, Sao Paulo 05508-000, SP, Brazil; [email protected] (P.A.V.S.); [email protected] (P.S.S.) 
First page
107
Publication year
2025
Publication date
2025
Publisher
MDPI AG
e-ISSN
23102861
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3171031728
Copyright
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.