Abstract

Human leukocyte antigen (HLA) polymorphism is hypothesized to be associated with diverse immune responses toward infectious diseases. Herein, by comparing against multiple subpopulation groups as control, we confirmed that HLA-B*15:27 and HLA-DRB1*04:06 were associated with coronavirus disease 2019 susceptibility in China. Both alleles were predicted to have weak binding affinities toward viral proteins.

Details

Title
The Association of Human Leukocyte Antigen and COVID-19 in Southern China
Author
Yu, Xueping 1 ; Ho, Kuoting 2 ; Shen, Zhongliang 3 ; Fu, Xiaoying 4 ; Huang, Hongbo 5 ; Wu, Delun 4 ; Lin, Yancheng 4 ; Lin, Yijian 5 ; Chen, Wenhuang 1 ; Su, Milong 6 ; Qiu, Chao 3 ; Zhuang, Xibin 5 ; Su, Zhijun 1 

1  Department of Infectious Disease, The First Hospital of Quanzhou, affiliated to Fujian Medical University, Quanzhou, Fujian, China 
2  HI. Q Biomedical Laboratory, Quanzhou, Fujian, China; School of Biomedical Science, Huaqiao University, Quanzhou, Fujian, China 
3  Department of Infectious Disease, Huashan Hospital, Fudan University, Shanghai, China 
4  HI. Q Biomedical Laboratory, Quanzhou, Fujian, China 
5  Department of Respiratory Disease, The First Hospital of Quanzhou, affiliated to Fujian Medical University, Quanzhou, Fujian, China 
6  Department of Clinical Laboratory, The First Hospital of Quanzhou, affiliated to Fujian Medical University, Quanzhou, Fujian, China 
Publication year
2021
Publication date
Sep 2021
Publisher
Oxford University Press
e-ISSN
23288957
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1093/ofid/ofab410
ProQuest document ID
3171173937
Copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.