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Abstract
Yeast cells have controllable biosorption on metallic ions during metabolism. However, few studies were dedicated to using yeast-regulated biomimetic mineralization process to control the strontium-doped positions in calcium phosphate microcapsules. In this study, the yeast cells were allowed to pre-adsorb strontium ions metabolically and then served as sacrificing template for the precipitation and calcination of mineral shell. The pre-adsorption enabled the microorganism to enrich of strontium ions into the inner part of the microcapsules, which ensured a slow-release profile of the trace element from the microcapsule. The co-culture with human marrow stromal cells showed that gene expressions of alkaline phosphatase and Collagen-I were promoted. The promotion of osteogenic differentiation was further confirmed in the 3D culture of cell-material complexes. The strategy using living microorganism as ‘smart doping apparatus’ to control incorporation of trace element into calcium phosphate paved a pathway to new functional materials for hard tissue regeneration.
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Details
1 School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China;; National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China
2 School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China;; Ministry of Education Key Laboratory of Biomedical Materials Science and Engineering, Guangzhou 510006, China
3 School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China;; School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China;
4 School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China;
5 National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China