Abstract

ABSTRACT

Background

The clinical manifestations of autosomal dominant polycystic kidney disease (ADPKD) usually appear in adulthood, however pediatric series report a high morbidity. The objective of the study was to analyze the clinical characteristics of ADPKD in young adults.

Methods

Family history, hypertension, albuminuria, estimated glomerular filtration rate (eGFR) and imaging tests were examined in 346 young adults (18–30 years old) out of 2521 patients in the Spanish ADPKD registry (REPQRAD). A literature review searched for reports on hypertension in series with more than 50 young (age <30 years) ADPKD patients.

Results

The mean age of this young adult cohort was 25.24 (SD 3.72) years. The mean age at diagnosis of hypertension was 21.15 (SD 4.62) years, while in the overall REPQRAD population was aged 37.6 years. The prevalence of hypertension was 28.03% and increased with age (18–24 years, 16.8%; 25–30 years, 36.8%). Although prevalence was lower in women than in men, the age at onset of hypertension (21 years) was similar in both sexes. Mean eGFR was 108 (SD 21) mL/min/1.73 m2, 38.0% had liver cysts and 3.45% of those studied had intracranial aneurysms. In multivariate analyses, hematuria episodes and kidney length were independent predictors of hypertension (area under the curve 0.75). The prevalence of hypertension in 22 pediatric cohorts was 20%–40%, but no literature reports on hypertension in young ADPKD adults were found.

Conclusions

Young adults present non-negligible ADPKD-related morbidity. This supports the need for a thorough assessment of young adults at risk of ADPKD that allows early diagnosis and treatment of hypertension.

Details

Title
Autosomal dominant polycystic kidney disease in young adults
Author
Martínez, Víctor 1   VIAFID ORCID Logo  ; Furlano, Mónica 2   VIAFID ORCID Logo  ; Sans, Laia 3   VIAFID ORCID Logo  ; Pulido, Lissett 4 ; García, Rebeca 5   VIAFID ORCID Logo  ; Pérez-Gómez, María Vanessa 6   VIAFID ORCID Logo  ; Sánchez-Rodríguez, Jinny 6 ; Blasco, Miquel 7   VIAFID ORCID Logo  ; Castro-Alonso, Cristina 8 ; Fernández-Fresnedo, Gema 9 ; Robles, Nicolás Roberto 10   VIAFID ORCID Logo  ; María Pau Valenzuela 11 ; Naranjo, Javier 12   VIAFID ORCID Logo  ; Martín, Nadia 13   VIAFID ORCID Logo  ; Pilco, Melissa 13   VIAFID ORCID Logo  ; Agraz-Pamplona, Irene 14   VIAFID ORCID Logo  ; González-Rodríguez, Juan David 15   VIAFID ORCID Logo  ; Panizo, Nayara 16 ; Fraga, Gloria 17 ; Fernández, Loreto 18 ; López, María Teresa 19 ; Dall'Anese, Cecilia 20 ; Ortiz, Alberto 6   VIAFID ORCID Logo  ; Torra, Roser 21   VIAFID ORCID Logo  ; Marcas, Luis 22 ; Rius, Asunción 23 ; Tomás, Patricia 24 ; García, Leonor 25 ; Luna, Enrique 26 ; Martín, María Adoración 27 ; Íñigo, Pablo 28 ; Martins, Judith 29 ; Ramos, Fernanda 30 ; García, Rosa 31 ; del Río García, Laura 32 ; María del Carmen Merino 33 ; Fernández-Reyes, M José 34 ; Madariaga, Leire 35 ; Canal, Cristina 36 ; Martínez, Ana María 37 ; Echarri, Rocío 38 ; Bouarich, Hanane 39 ; Cabezas, Antonio 40 

1  Nephrology Department, Hospital Universitario Virgen de la Arrixaca , Murcia , Spain 
2  Inherited Kidney Diseases, Nephrology Department, Fundació Puigvert, Institut d'Investigació Biomèdica Sant Pau (IIB-SANT PAU ) 
3  Nephrology Department, Hospital del Mar , Barcelona , Spain 
4  Nephrology Department, Hospital Universitario Joan XXIII , Tarragona , Spain 
5  Nephrology Department, Hospital La Mancha-Centro , Alcázar de San Juan, Spain 
6  Nephrology Department, IIS-Fundación Jiménez Diaz, Universidad Autónoma de Madrid , IRSIN, RICORS40, Madrid , Spain 
7  Nephrology and Kidney Transplantation Department, Hospital Clínic, Institute of Biomedical Research August Pi i Sunyer (IDIPABS), University of Barcelona , Barcelona , Spain 
8  Nephrology Department, Hospital Universitario Doctor Peset , Valencia , Spain 
9  Nephrology Department, Hospital Universitario Marqués de Valdecilla , Santander , Spain 
10  Nephrology Department, Hospital Universitario de Badajoz , Badajoz , Spain 
11  Nephrology Department, Hospital Universitari Parc Taulí , Sabadell , Spain 
12  Nephrology Department, Hospital Universitario Puerta del Mar , Cádiz, Spain 
13  Nephrology Department, Hospital Universitari de Girona Dr Josep Trueta , Gerona, Spain 
14  Nephrology Department, Hospital Valle de Hebrón , Barcelona , Spain 
15  Pediatric Nephrology Department, Hospital Universitario Santa Lucía , Cartagena , Spain 
16  Nephrology Department, Hospital Universitari i Politècnic la Fe , Valencia , Spain 
17  Pediatric Nephrology Department, Hospital Santa Creu i Sant Pau , Barcelona , Spain 
18  Nephrology Department, Hospital Príncipe de Asturias , Alcalá de Henares, Spain 
19  Nephrology Department, Hospital Rey Juan Carlos , Móstoles, Spain 
20  Nephrology Department, Hospital San Pedro , Logroño, Spain 
21  Inherited Kidney Diseases, Nephrology Department, Fundació Puigvert, Institut d’Investigació Biomèdica Sant Pau (IIB-SANT PAU) , Universitat Autònoma de Barcelona, Barcelona , Spain 
22  Nephrology Department, Hospital Universitario Joan XXIII , Tarragona, Spain 
23  Nephrology Department , Hospital de Castellón, Spain 
24  Nephrology Department, Hospital Universitario de Valencia , Valencia, Spain 
25  Pediatric Nephrology Department , Hospital de Sagunto, Valencia, Spain 
26  Nephrology Department, Hospital Universitario de Badajoz , Spain 
27  Nephrology Department, Hospital de Poniente , El Ejido, Spain 
28  Nephrology Department, Hospital Universitario Lozano Blesa , Zaragoza, Spain 
29  Nephrology Department , Hospital de Getafe, Madrid, Spain 
30  Nephrology Department, Hospital Universitario Reína Sofía , Murcia, Spain 
31  Nephrology Department, Hospital de Palamós , Gerona, Spain 
32  Nephrology Department, Hospital San Agustín , Avilés, Spain 
33  Nephrology Department , Hospital de Cabueñes, Gijón, Spain 
34  Nephrology Department , Hospital de Segovia, Segovia, Spain 
35  Pediatric Nephrology Departament , Hospital de Cruces, Barakaldo, Spain 
36  Nephrology Department , Fundació Puigvert, Barcelona, Spain 
37  Nephrology Department , Hospital Arnau de Vilanova, Valencia, Spain 
38  Nephrology Department , Hospital Infanta Sofía, San Sebastián de los Reyes, Spain 
39  Nephrology Department, Hospital Universitario Príncipe de Asturias , Alcalá de Henares, Spain and 
40  Nephrology Department , Hospital Vinalopó, Elche, Spain 
Pages
985-995
Publication year
2023
Publication date
Jun 2023
Publisher
Oxford University Press
ISSN
20488505
e-ISSN
20488513
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1093/ckj/sfac251
ProQuest document ID
3171846721
Copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of the ERA. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.