Abstract

The interpretation of long-acting cabotegravir and rilpivirine concentrations is complicated by the lack of consensus on the threshold to consider. Building on real-world therapeutic drug monitoring data and documented virologic failures, this article provides a reappraisal of the existing thresholds and guidance for the interpretation of cabotegravir and rilpivirine concentrations.

Details

Title
Guidance for the Interpretation of Long-Acting Cabotegravir and Rilpivirine Concentrations Based on Real-World Therapeutic Drug Monitoring Data and Documented Failures
Author
Thoueille, Paul 1 ; Cavassini, Matthias 2 ; Guidi, Monia 1 ; Buclin, Thierry 1 ; Girardin, François R 1 ; Decosterd, Laurent A 1 ; Marzolini, Catia 1 

 Service and Laboratory of Clinical Pharmacology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital and University of Lausanne , Lausanne , Switzerland 
 Service of Infectious Diseases, Department of Medicine, Lausanne University Hospital and University of Lausanne , Lausanne , Switzerland 
Publication year
2024
Publication date
Feb 2024
Publisher
Oxford University Press
e-ISSN
23288957
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3171905535
Copyright
© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.