Skin reaction to COVID-19 vaccine: a report of 4 cases

Abstract

Since the beginning of the covid-vaccine campaign, a lot of local and systemic dermatologic reactions happening after the administration of Corovirus disease 2019 (COVID-19) vaccines have been described, even if their exact biological mechanism is still debated. In this paper, we report four cases of cutaneous manifestations that arose within ten days after the first dose of messenger R (mR)-based COVID-19 vaccition: one case of giant urticaria, one case of head and neck redness, and two cases of Erythema multiforme. In our experience, these reactions were mild and transient and all of them resolved, not recurring after the second dose, so these manifestations shouldn’t be considered as an absolute contraindication to the second dose of vaccine, that to date is fundamental.