Abstract
[1] Ring finger protein 115 (RNF115) is a RAB7 target protein also known as breast cancer-associated gene 2 (BCA2). In the present study, we report that RNF115 is a negative regulator of basal autophagy in hepatoma cells. Inactivating RNF115 promoted autophagic activity by enhancing RAB7–HOPS complex binding and ATG14 activities [Figure 1], which inhibited hepatoma cell growth in vivo and in vitro and provided an experimental foundation for hepatocellular carcinoma treatment by targeting RNF115. Zongming Zhang, Department of General Surgery, Beijing Electric Power Hospital, State Grid Corporation of China, Capital Medical University, Beijing 100073, China E-Mail: [email protected]; Bin Zhu, Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China E-Mail: [email protected]; Yingyu Chen, Center for Human Disease Genomics, Peking University, Beijing 100191, China E-Mail: [email protected] How to cite this article:
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1 Department of Immunology, Peking University School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Peking University, Beijing 100191, China
2 Department of General Surgery, Beijing Electric Power Hospital, State Grid Corporation of China, Capital Medical University, Key Laboratory of Geriatrics (Hepatobiliary Diseases), China General Technology Group, Beijing 100073, China
3 Medical and Healthy Analytical Center, Peking University, Beijing 100191, China
4 Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
5 Department of Immunology, Peking University School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Peking University, Beijing 100191, China; Center for Human Disease Genomics, Peking University, Beijing 100191, China