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Abstract
Hospital-acquired infections (HAIs) pose significant risks to patients, leading to increased morbidity, mortality, prolonged hospital stays, and elevated healthcare costs. Recent advancements in infection control practices have focused on reducing HAI incidence through enhanced strategies for hand hygiene, isolation precautions, environmental cleaning, and targeted interventions for specific infections. Hand hygiene remains the most effective method for preventing pathogen transmission, with alcohol-based hand rubbing demonstrating greater efficacy compared to traditional handwashing. Isolation practices, such as contact precautions for multidrug-resistant organisms, have been widely recommended, although their specific contribution to reducing transmission remains unclear. Environmental cleaning has gained attention, with studies highlighting the importance of monitoring cleaning performance and utilizing novel technologies like hydrogen peroxide vapor, ultraviolet light decontamination, and antimicrobial surfaces. Ventilator-associated pneumonia prevention has been addressed through the implementation of care bundles, including head-of-bed elevation, daily sedation interruption, and oral care with chlorhexidine. Central line-associated bloodstream infections have seen substantial reductions following the widespread adoption of prevention bundles focusing on hand hygiene, maximal barrier precautions, and prompt removal of unnecessary lines. Clostridioides difficile infection (CDI) remains a significant challenge, with the emergence of the highly virulent BI/NAP1/027 strain. Strategies to prevent CDI include effective hand hygiene, isolation precautions, and environmental decontamination using chlorine-based disinfectants or novel technologies. Despite progress, challenges persist in improving adherence to evidence-based practices and confirming the impact of new technologies on reducing HAI rates. A multidisciplinary approach encompassing robust infection control policies, antimicrobial stewardship, and healthcare worker education is crucial for sustaining progress in preventing HAIs and ensuring patient safety in hospital settings.
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