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© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Simple Summary

AvBD11 is an atypical, double-sized defensin predicted to have two motifs associated with β-defensins and six disulfide bonds. We expressed AvBD11 using Escherichia coli and examined the effects of different concentrations of AvBD11 on cytokine expression in ex vivo and in vivo erythrocytes from chickens infected with avian influenza subtype H9N2. The results showed that the addition of different concentrations of AvBD11 caused changes in cytokine expression at different times. It is suggested that AvBD11 is not only an antimicrobial peptide but may also be an immunomodulator.

Details

Title
Effect of Chicken AvBD11 on the Cytokines in the Erythrocytes of Chickens Infected with the Avian Influenza Virus of the Subtype H9N2
Author
Yu, Jie  VIAFID ORCID Logo  ; Sheng-Qing Luo; Wen-Jun, Xiang; Zi-Xuan Meng; Wang, Ying; Jian-Le, Ren  VIAFID ORCID Logo  ; Yu-Jun, Zhao; Rui-Wen, Fan; Niu, Sheng; Wen-Xia, Tian  VIAFID ORCID Logo 
First page
1023
Publication year
2025
Publication date
2025
Publisher
MDPI AG
e-ISSN
20762615
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3188769421
Copyright
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.