Abstract

We have recently demonstrated that the alkaloid rhynchophylline (RHY; purified from Uncaria plants) induces sleep and modifies electrocorticographic (ECoG) activity throughout the 24-h day in a vigilance state-dependent manner in wild-type mice. We here asked whether this alkaloid impacts wake/sleep variables in the absence of the cell adhesion protein EPHA4, via ECoG recording in EphA4 knockout (KO) mice submitted to the same RHY treatment contemporaneously to the wild-type mice (littermates). We uncover that RHY decreases time spent awake and increases time spent in slow wave sleep in EphA4 KO mice and alters the 24-h time course of ECoG activity during wakefulness and sleep states. These observations are similar to the reported effects of RHY in wild-type littermate animals, which strongly supports that RHY-driven sleep alterations are not dependent on the presence of EPHA4.

Details

Title
Sleep-inducing effect of Rhynchophylline in EphA4 knockout mice
Author
Ballester Roig, Maria Neus 1 ; Mongrain, Valérie 1 

 Department of Neuroscience, Université de Montréal , Montréal, QC , Canada 
Publication year
2023
Publication date
2023
Publisher
Oxford University Press
e-ISSN
26325012
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3191384714
Copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of Sleep Research Society. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.