Abstract

China and the world are facing severe population aging and an increasing burden of age-related diseases. Aging of the brain causes major age-related brain diseases, such as neurodegenerative diseases and stroke. Identifying biomarkers for the effective assessment of brain aging and establishing a brain aging assessment system could facilitate the development of brain aging intervention strategies and the effective prevention and treatment of aging-related brain diseases. Thus, experts from the Aging Biomarker Consortium (ABC) have combined the latest research results and practical experience to recommend brain aging biomarkers and form an expert consensus, aiming to provide a basis for assessing the degree of brain aging and conducting brain-aging-related research with the ultimate goal of improving the brain health of elderly individuals in both China and the world.

Details

Title
A framework of biomarkers for brain aging: a consensus statement by the Aging Biomarker Consortium
Author
Yu-Juan, Jia 1 ; Wang, Jun 1 ; Jun-Rong, Ren 1 ; Chan, Piu 2 ; Chen, Shengdi 3 ; Xiao-Chun, Chen 4 ; Chhetri, Jagadish K 2 ; Guo, Junhong 5 ; Guo, Qihao 6 ; Jin, Lingjing 7 ; Liu, Qiang 8 ; Ma, Wenlin 9 ; Mao, Zhiyong 10 ; Song, Moshi 11 ; Song, Weihong 12 ; Tang, Yi 13   VIAFID ORCID Logo  ; Wang, Difei 14 ; Wang, Peijun 15 ; Xiong, Lize 16 ; Ye, Keqiang 17 ; Zhang, Junjian 18 ; Zhang, Weiqi 19 ; Zhang, Xiaoqing 20 ; Zhang, Yunwu 21 ; Zhang, Zhanjun 22   VIAFID ORCID Logo  ; Zhang, Zhuohua 23 ; Zheng, Jialin 24 ; Guang-Hui Liu 25 ; Sun, Yi Eve 26 ; Yan-Jiang, Wang 27 ; Pei, Gang 28 

 Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University , Chongqing 400042 , China 
 National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University , Beijing 100053 , China 
 Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 , China 
 Department of Neurology, Union Hospital of Fujian Medical University , Fuzhou 350001 , China 
 Department of Neurology, First Affiliated Hospital, Shanxi Medical University , Taiyuan 030001 , China 
 Department of Gerontology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai 200233 , China 
 Department of Neurology and Neurological Rehabilitation, Shanghai Disabled Persons’ Federation Key Laboratory of Intelligent Rehabilitation Assistive Devices and Technologies, Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University, School of Medicine , Shanghai 200092 , China 
 Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei 230026 , China 
 Department of Cardiology, Shanghai Tongji Hospital, Tongji University School of Medicine , Shanghai 200092 , China 
10  Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University , Shanghai 200092 , China 
11  State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101 , China 
12  Institute of Aging, Key Laboratory of Alzheimer’s Disease of Zhejiang Province, Zhejiang Clinical Research Center for Mental Disorders, School of Mental Health and The Affiliated Kangning Hospital, Wenzhou Medical University, Oujiang Laboratory , Wenzhou, Zhejiang 325035 , China 
13  Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders , Beijing 100053 , China 
14  Department of Gerontology, Shengjing Hospital of China Medical University, Shenyang 110000 , China 
15  Department of Radiology, Tongji Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University , Shanghai 200092 , China 
16  Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, Tongji University , Shanghai 200434 , China 
17  Faculty of Life and Health Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Science , Shenzhen 518055 , China 
18  Department of Neurology, Zhongnan Hospital of Wuhan University , Wuhan 430071 , China 
19  CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation , Beijing 100101 , China 
20  Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital, School of Medicine, Tongji University , Shanghai 200120 , China 
21  Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University , Xiamen 361102 , China 
22  State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University , Beijing 100875 , China 
23  Hunan Key Laboratory of Molecular Precision Medicine, Department of Critical Care Medicine, Xiangya Hospital, Central South University , Changsha 410008 , China 
24  Center for Translational Neurodegeneration and Regenerative Therapy, Tongji Hospital affiliated to Tongji University School of Medicine , Shanghai 200072 , China 
25  University of Chinese Academy of Sciences , Beijing 100049 , China 
26  Stem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine , Shanghai 200065 , China 
27  Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University , Chongqing 400042 , China 
28  Collaborative Innovation Center for Brain Science, School of Life Science and Technology, Tongji University , Shanghai 200092 , China 
Publication year
2023
Publication date
Jun 2023
Publisher
Oxford University Press
e-ISSN
27551733
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3191384725
Copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of Higher Education Press. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.