Abstract

We present a case of a PTH-related peptide (PTH-rp) producing uterine myoma, leading to hypercalcemia in pregnancy. Our patient presented with dehydration, hypotension, delirium, and malnutrition. Due to a serum calcium level of 17.9 mg/dL (4.48 mmol/L) (reference range 8.8-11.2 mg/dL; 2.20-2.80 mmol/L), prompt treatment with hydration and calcitonin was initiated. The patient went into labor before we could consider other treatment options. Although uncommon in pregnancy, it is of great importance to identify hypercalcemia since it is related to a high risk of maternal and neonatal morbidity and mortality. Because bisphosphonates are contraindicated in pregnancy, hydration and calcitonin are the cornerstones of treatment for PTH-rp-induced hypercalcemia.

Details

Title
Hypercalcemia in Pregnancy Caused by a Uterine Myoma
Author
van der Leij, Stephanie 1   VIAFID ORCID Logo  ; Hertog, Doenja 1 

1  Department of Endocrinology, University Medical Center, Utrecht University , Utrecht, CX 3584 , The Netherlands 
Publication year
2024
Publication date
Sep 2024
Publisher
Oxford University Press
e-ISSN
27551520
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1210/jcemcr/luae126
ProQuest document ID
3191840965
Copyright
© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.