Abstract
Introduction
High-grade serous ovarian cancer (HGSOC) is characterized by high mortality and prevalent recurrences. This study investigates the prognostic value of phosphoglycerate dehydrogenase (PHGDH) in HGSOC which has been linked to metabolic reprogramming and recurrences in other cancers.
Methods
Data from 306 patients with advanced-stage HGSOC treated between 2008 and 2015 were analyzed. PHGDH expression levels were determined using immunohistochemistry and categorized as “low” or “high.”
Results
PHGDH-high was associated with higher FIGO stage and increased use of neoadjuvant chemotherapy. Patients with PHGDH-high tumors had significantly worse survival than PHDH-low, even after adjusting for confounding factors.
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Details
1 Department of Research and Development, Netherlands Comprehensive Cancer Organization (IKNL) , 3511 DT Utrecht , The Netherlands
2 Gynecological Oncology Laboratory, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI) , 3000 Leuven , Belgium
3 Department of Medical Oncology, The Netherlands Cancer Institute , 1066 CX Amsterdam , The Netherlands
4 GROW, School for Oncology and Reproduction , 6229 HX Maastricht , The Netherlands
5 Department of Molecular Pathology, The Netherlands Cancer Institute , 1066 CX Amsterdam , The Netherlands