Evaluation of the Effectiveness of Some Types of Sugars on the Lipid Profile in Animals Induced with Diabetes and Obesity

Abstract

From March 6th to April 28th, 2022, researchers at the University of Fallujah’s College of Veterinary Medicine and postgraduate laboratories studied the effects of various sugars on blood lipid profiles (TG, Cho, HDL, LDL, VLDL) in animals. The rats were given either a standard diet or one that had glucose replaced with sugar (stevia, inulin, xylitol), and the goal was to treat type 2 diabetes and obesity. Six rats served as controls and were given the standard diet. For the remaining 24 rats, one group received injections of alloxan at a dosage of 150 mg/kg, causing diabetes; another group followed a conventional diet supplemented with 30% more fat, leading to obesity. There were a total of forty-six rats distributed across the four groups. What followed was the protocol for the treatments: group of healthy individuals, One group of diabetic animals received a meal containing 12 mg/kg of stevia, another group received 160 mg/kg of inulin, and a third group received 100 mg/kg of xylitol; all of these groups served as controls for the diabetic animals. Each of the four groups of obese people underwent the identical treatments, except that they followed a regular diet and had different amounts of glucose replaced with the sugar alternatives listed above. The nutritional experiment lasted 50 days after the produced disorders had been confirmed, during which time the blood lipid profile standards (Tri, Cho, HDL, LDL, VLDL) were estimated. Blood lipid profile standards (Tri, Cho, LDL, VLDL) increased significantly and HDL decreased significantly in groups of experimental animals who were induced to be overweight and diabetic. The treatment that was fed feed containing inulin sugar came out on top in the obesity groups, followed by the treatment that was fed feed containing xylitol sugar, and finally the treatment that was fed feed containing stevia. All of these treatments significantly reduced the aforementioned values and increased the value of (HDL). When it came to the diabetic groups, the inulin sugar treatment also came out on top, followed by the stevia treatment, and finally the xylitol sugar treatment. All three of these treatments significantly reduced the aforementioned values and increased the HDL worth.