Full text

Turn on search term navigation

© 2025 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

INTRODUCTION:

Delayed postpolypectomy bleeding occurs in approximately 1%–2% of all patients undergoing colonoscopic polypectomy, and this rate increases to 6% in patients with large (>2 cm) colon polyps. Sucralfate can protect the mucosa and promote its healing. This study was conducted to investigate whether colonoscopic spraying of sucralfate powder on polypectomy wounds can prevent delayed postoperative bleeding.

METHODS:

This randomized controlled trial included patients with polyps (size ≥0.5 cm) who had undergone colonoscopic polypectomy at our hospital between May 2023 and January 2024. After polypectomy, the patients received standard treatment for immediate bleeding. Then, they were randomly allocated to either a sucralfate group (prophylactic spraying of sucralfate powder [3 g] on polypectomy wounds) or a control group. All patients were monitored for delayed bleeding within 28 days after colonoscopy.

RESULTS:

A total of 160 patients were divided into the sucralfate and control groups (80 per group). The baseline characteristics were balanced between the groups. The rate of delayed postpolypectomy bleeding (0% vs 6.3%, respectively; P = 0.029) and postpolypectomy overt bloody stool (2.4% vs 18.8%, respectively; P = 0.001) were lower in the sucralfate group than in the control group. The duration of freedom from delayed bleeding was longer in the sucralfate group than in the control group (P = 0.024). Multivariate Cox regression analysis confirmed the additional sucralfate spray as an independent factor against postpolypectomy overt bloody stool (relative risk, 0.03; 95% confidence interval, 0.003–0.43; P = 0.009).

DISCUSSION:

Colonoscopic spraying of sucralfate powder is a safe approach with potential to reduce the risk of delayed postpolypectomy bleeding. Trial registration: NCT05817656.

abstract-type="graphical">

Details

Title
Clinical Trial: Precise Administration of Sucralfate Powder in Prevention of Delayed Postpolypectomy Bleeding. A Randomized Controlled Trial
Author
Hsueh-Chien, Chiang 1 ; Po-Jun, Chen 2 ; Er-Hsiang, Yang 2 ; Tzu-Ling, Kuo 3 ; Hsieh Ming-Tsung 2 ; Jui-Wen, Kang 2 ; Cheng Hsiu-Chi 4 ; Wei-Lun, Chang 1 ; Wei-Ying, Chen 5 ; Chiu Hung-Chih 2 ; Meng-Ying, Lin 2 ; Tzu-Chun, Hong 2 ; Chien-Ming, Chiang 2 ; Chen, Wei-Chih 2 ; Kuan-Kai, Huang 2 ; Meng-Hsuan, Lu 2 ; Wu Ming-Hsuan 2 ; Chen, Chiung-Yu 2 ; Xi-Zhang, Lin 2 ; Chiao-Hsiung, Chuang 2   VIAFID ORCID Logo 

 Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan;; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
 Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
 Department of Pharmacy, National Cheng Kung University Hospital, Tainan, Taiwan
 Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan;; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan;; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 
 Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan;; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 
Pages
e00818
Section
Article
Publication year
2025
Publication date
Apr 2025
Publisher
Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
e-ISSN
2155384X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3194116011
Copyright
© 2025 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.