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© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background and Objectives: Febrile seizures (FS) are neuronal disturbances frequently associated with abnormal electroencephalographic activity (EEG) as spike-wave discharges (SWDs). Fish oil (FO) has high amounts of omega-3 fatty acids (θ-3), and its effects on FS alterations are poorly understood. The aim of this work was to evaluate the effect of long-term FO supplementation on the EEG of the amygdala of adult male rats with early-life FS. Materials and Methods: Progenitor female Wistar rats, from puberty to gestation and delivery, were fed daily with a commercial diet supplemented with either fish oil (FO), palm oil (PO), or deionized water (CTRL). After parturition, male pups were exposed for 30 min to hyperthermia (HP) and then returned to their dams. After weaning, pups were fed a commercial diet and the respective treatments up to 155 days of age when electrodes were implanted in the amygdala. Results: During early life HP, the PO and CTRL groups reached maximal core temperature (CT) in comparison with the FO group. Furthermore, the FO group only has fewer myoclonus and long latency to adopt an uncontrolled posture. At an adult age, the FO group with early-life FS scored shorter periods of SWDs in amygdala EEG but without seizures and presented minor values of absolute power than the PO and CTRL groups. Conclusions: In adult rats, the long-term supplementation of FO minimizes the deleterious behavioral effects caused by early-life FS and decreases the occurrence and amplitude of SWDs in the EEG of the amygdala.

Details

Title
Long-Term Fish Oil Supplementation Attenuates Spike Wave Discharges in the Amygdala of Adult Rats with Early-Life Febrile Seizures
Author
Flores-Mancilla, Leopoldo Eduardo 1 ; Hernández-González Marisela 2 ; Guevara-Pérez, Miguel Ángel 3 ; Bonilla-Jaime Herlinda 3   VIAFID ORCID Logo  ; Gaytán-Pacheco Noemí 4   VIAFID ORCID Logo  ; Reyes-Estrada, Claudia Araceli 4   VIAFID ORCID Logo  ; Pacheco-Moisés, Fermín Paul 5   VIAFID ORCID Logo 

 Unidad Académica de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Ejido la Escondida, Zacatecas 98160, CP, Mexico 
 Instituto de Neurociencias, Centro Universitario de Ciencias Biológicas y Agropecuarias, Universidad de Guadalajara, Francisco de Quevedo No. 180, Col. Arcos Vallarta, Guadalajara 44130, CP, Mexico; [email protected] 
 Departamento de Biología de la Reproducción, División Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, av. San Rafael Atlixco No. 186, Col. Vicentina, Alcaldía Iztapalapa, Ciudad de México 09340, CP, Mexico; [email protected] (M.Á.G.-P.); [email protected] (H.B.-J.) 
 Unidad Académica de Ciencias Químicas, Universidad Autónoma de Zacatecas, Ejido la Escondida, Zacatecas 98160, CP, Mexico; [email protected] (N.G.-P.); [email protected] (C.A.R.-E.) 
 Departamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Guadalajara 44430, CP, Mexico; [email protected] 
First page
395
Publication year
2025
Publication date
2025
Publisher
MDPI AG
e-ISSN
20763425
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3194500182
Copyright
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.