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© 2025 by the authors. Published by MDPI on behalf of the Lithuanian University of Health Sciences. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background and Objectives: Chronic obstructive pulmonary disease (COPD) poses a significant healthcare challenge worldwide, frequently leading to exacerbations necessitating intensive care unit admissions for potentially life-threatening complications. We aimed to investigate correlations between laboratory parameters, bacteriological agents, ventilation mode, and survival rates among COPD patients admitted to the ICU. Materials and Methods: Data were collected from the Pulmonology Department of Mures Clinical County Hospital, Romania, from 1 January 2022 to 30 October 2023. Eighty-four COPD patients required ICU transfer, except for concurrent SARS-CoV-2 infections. Results: Ventilation modes exhibited a significant correlation with specific bacteriological agents, orotracheal intubation being more prevalent in infections with Acinetobacter baumanii, Staphylococcus aureus, and Streptococcus pneumoniae (p < 0.001). Negative cultures were predominantly found in patients managed with non-invasive ventilation. Laboratory parameters revealed an association between elevated white blood cell counts and bacteriological superinfection, particularly with Escherichia coli (p < 0.001). Different bacteriological agents had different survival rates. Patients infected with Acinetobacter baumanii exhibited the highest mortality rate, while those with Staphylococcus aureus had the lowest (p < 0.01). Conclusions: The importance of prompt evaluation of laboratory parameters and bacteriological findings is underscored by these findings, particularly in ICU settings where ventilation and bacteriological profiles influence patient outcomes. The identification of elevated WBC counts is a marker of bacterial superinfection. The association between specific bacterial agents and ventilation modes highlights the importance of tailored treatment based on microbial profiles. These insights can be applied to refine treatment protocols and enhance survival rates in severe COPD exacerbations that require ICU management.

Details

Title
Analyzing Clinical Parameters and Bacterial Profiles to Uncover the COPD Exacerbations: A Focus on Intensive Care Unit Challenges
Author
Dragoș, Huțanu 1   VIAFID ORCID Logo  ; Hédi-Katalin, Sárközi 1 ; Vultur Mara Andreea 1   VIAFID ORCID Logo  ; Adrian-Horațiu, Sabău 2 ; Cocuz Iuliu Gabriel 2   VIAFID ORCID Logo  ; Mărginean Corina 3 ; Andra-Maria, Chelemen 4 ; Budin, Corina Eugenia 2   VIAFID ORCID Logo 

 Pulmonology Department, “George Emil Palade” University of Medicine Pharmacy, Science and Technology of Târgu Mureș, 540139 Târgu Mureș, Romania; [email protected] (D.H.); [email protected] (M.A.V.) 
 Pathophysiology Department, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540139 Târgu Mureș, Romania; [email protected] (A.-H.S.); [email protected] (I.G.C.); [email protected] (C.E.B.) 
 Oncology and Palliative Care Department, “George Emil Palade” University of Medicine Pharmacy, Science and Technology of Târgu Mureș, 540139 Târgu Mureș, Romania; [email protected] 
 Faculty of Medicine, “George Emil Palade” University of Medicine Pharmacy, Science and Technology of Târgu Mureș, 540139 Târgu Mureș, Romania; [email protected] 
First page
669
Publication year
2025
Publication date
2025
Publisher
MDPI AG
ISSN
1010660X
e-ISSN
16489144
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3194625148
Copyright
© 2025 by the authors. Published by MDPI on behalf of the Lithuanian University of Health Sciences. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.