Evaluation of intermittent hemodialysis therapy in the bypass mode in dogs with chronic kidney disease in uremic crisis

Abstract

Background

This study aimed to assess the safety of intermittent hemodialysis via the bypass mode in dogs with chronic kidney disease during uremic crisis.

Results

Fourteen dogs with chronic kidney disease in uremic crisis were selected. The dogs were allocated into two experimental groups: intermittent hemodialysis without bypass mode (IHD group without bypass) and intermittent hemodialysis with bypass mode (IHD group with bypass). Data were collected during the first dialysis session at 10 min pre-session (M0), 30 min (M1), 60 min (M2), 120 min (M3), 180 min (M4), and 240 min (M5) after the session began and 10 min post-session (M6). An increase in rectal temperature was observed at certain moments in both groups. The hemogram revealed a decrease in red blood cells, total protein, and platelets in both groups, whereas hemoglobin and hematocrit decreased at M6 only in the IHD group with bypass. Urea, creatinine, and phosphorus were reduced at M6 in both groups. An increase in blood pH, sodium bicarbonate, and excess base at M6 (10 min post-session) was observed in both groups. The IHD group with bypass exhibited a significantly lower body weight. No significant differences were observed in session time or final URR between the groups.

Conclusions

The results of this study support the hypothesis that IHD with the bypass mode is safe and effective in CKD dogs with uremic crisis. This approach minimizes complications such as dialysis disequilibrium syndrome (DDS) while not causing hemodynamic or laboratory impairments under the executed conditions.