Full text

Turn on search term navigation

© 2025 mums.ac.ir All rights reserved This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Introduction The compound iodine-123-labelled N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4- iodophenyl) nortropane (123I-FP-CIT) has high affinity for the dopamine transporter (DAT). [...]123I-FP-CIT is a useful tool for assessing the status of presynaptic nigrostriatal dopaminergic terminals and is widely used in the diagnosis of Parkinson’s disease (PD) and parkinsonian syndrome. 123I-FP-CIT also exhibits a significant affinity for the serotonin transporter (SERT) (2, 3). Methods Participants The study involved 17 healthy subjects (mean±SD; 72±9.2 years old, 8 males, 9 females) and 11 patients with MSA (60±9.2 years old, 5 males, 6 females) who underwent head MRI and DAT SPECT (including head CT for CT-AC) in the ‘Multicentre joint study targeting healthy adult volunteers for collecting 123I- FP-CIT-SPECT healthy adult data (medical research ethical review: receipt number HM16-254)’ and the description of MSA-related applications. Changes in time per unit volume in compartment 3 are represented by the following set of differential equations (see the Appendix for details): dC3dt=1V2konf2C2Bmax-C3V2-1V2koffC3V2⋯(1) Considering the equilibrium state 3 h after injection (3), the relationships between Bmax and rate constants were expressed by setting the derivatives to zero in Eq. 1. The reason for setting the occipital as the reference region is that 1) it is an area that is not easily affected by MSA, and 2) it is also commonly used as a reference in PD. Next, Eq. 2A was used to subtract the reference value of the occipital lobe from the SPECT pixel value (123I-FP-CIT accumulation) per SPECT image pixel, and the ratio relative to the reference site of the occipital lobe was calculated and Vitria (Canon Medical Systems) was used to create an SBR image (formulas 3 and 4 below) (Figure 2).

Details

Title
Use of the specific binding ratio distribution to characterise multiple system atrophy in advanced iodine-123-labelled N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane serotonin transporter imaging
Author
Takahashi, Kazuya 1 ; Ishiguro Masanobu 2 ; Inui Yoshitaka 3 ; Ichihara Takashi 3 ; Shang Cong 3 ; Nagao Ryunosuke 4 ; Mizutani Yasuaki 4 ; Ito Mizuki 4 ; Watanabe Hirohisa 4 ; Motomura Nobutoku 5 ; Toyama, Hiroshi 3 

 Department of Radiology, Fujita Health University School of Medicine, Aichi, Japan, Kazuya Takahashi and Masanobu Ishiguro contributed equally to this study. 
 Section of Radiology, Fujita Health University Hospital, Aichi, Japan, Kazuya Takahashi and Masanobu Ishiguro contributed equally to this study. 
 Department of Radiology, Fujita Health University School of Medicine, Aichi, Japan 
 Department of Neurology, Fujita Health University School of Medicine, Aichi, Japan 
 Canon Medical Systems, Otawara, Tochigi, Japan 
University/institution
U.S. National Institutes of Health/National Library of Medicine
First page
33
End page
41
Publication year
2025
Publication date
2025
ISSN
23225718
e-ISSN
23225726
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3203754474
Copyright
© 2025 mums.ac.ir All rights reserved This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.