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Copyright © 2025, Keche et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Cryptococcus neoformans, an encapsulated yeast-like fungus, can induce a varied array of symptoms like meningitis, cryptococcomas of the brain, spinal cord granuloma, and disseminated disease, more so in people with impaired immune systems. Nonetheless, osseous lesions are rare. A 27-year-old male presented with a painful ulcer on his left lateral ankle. His medical history revealed leprosy for the last three years. The patient underwent an incisional biopsy and surgical debridement, and both the samples grew Cryptococcus neoformans on culture. Cryptococcal osteomyelitis involving the calcaneus and tibia was established. The patient was treated with liposomal amphotericin B followed by fluconazole.

Cryptococcal osteomyelitis, though uncommon, should be included in the differential diagnosis of chronic osteolytic lesions for optimal patient care. This case highlighted that early diagnosis and confirmation through microbiological investigations are crucial for the successful management of these rare and potentially debilitating infections, even in immunocompetent individuals.

Details

Title
Microbiological Diagnosis: A Key to Successfully Managing Cryptococcal Osteomyelitis Coexisting With Leprosy
Author
Keche Archana 1 ; Sarathi Sushree 1 ; Soma, Jana 1 ; Gupta Yashita 2 

 Microbiology, All India Institute of Medical Sciences, Raipur, Raipur, IND 
 Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Raipur, Raipur, IND 
University/institution
U.S. National Institutes of Health/National Library of Medicine
Publication year
2025
Publication date
2025
Publisher
Springer Nature B.V.
e-ISSN
21688184
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3204324409
Copyright
Copyright © 2025, Keche et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.