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Copyright © 2025 Tuan Minh Vo et al. International Journal of Hypertension published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License (the “License”), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/

Abstract

Objective: To assess serum magnesium mean levels in pregnant women with severe preeclampsia at three landmarks: prior to MgSO4 intake, 30 min, and 6 h postintake of loading dose plus maintenance dose.

Methodology: This cross-sectional study collected blood samples over a timeframe of 0–6 h from 64 pregnant women diagnosed with severe preeclampsia who were receiving MgSO4 therapy at the emergency management department of Hung Vuong Hospital, Vietnam, in the period of November 2023 to April 2024. Serum magnesium levels were measured three times in the timeframe.

Results: Prior to MgSO4 intake, the serum magnesium mean level was 0.75 ± 0.13 mmol/L. At 30 min postloading dose intake plus maintenance, the level increased to 1.65 ± 0.32 mmol/L, and at 6 h, 1.6 ± 0.34 mmol/L, where 17.2% of patients had a serum magnesium level of 2 mmol/L or higher.

Conclusion: There were no eclampsia incidents in patients with severe preeclampsia treated with a regimen of a loading dose of 4.5 g MgSO4 followed by a 1 g-hourly maintenance. Nevertheless, about 17% of participants achieved the desired threshold of 2 mmol/L, indicating a need for additional research to refine the loading and maintenance doses of MgSO4 for better management of severe preeclampsia in Vietnamese women.

Details

Title
Assessment of Serum Magnesium Mean Levels at Pre- and Postmagnesium Sulfate Uptake for Eclampsia Prevention: A Cross-Sectional Study
Author
Vo, Tuan Minh 1   VIAFID ORCID Logo  ; Du Van Tran 1   VIAFID ORCID Logo  ; Nguyen, Dat Quoc 2 ; Toan Thi Nguyen 1 ; Mo Ha Nguyen 1 ; Thanh Tan Nguyen 3 ; Liem Ba Le 4 

 Department of Obstetrics and Gynecology University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam 
 Department of Epidemiology University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam 
 Department of Clinical Pathology University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam 
 Department of Emergency Hung Vuong Hospital Ho Chi Minh City Vietnam 
Editor
Shamreen Naaz
Publication year
2025
Publication date
2025
Publisher
John Wiley & Sons, Inc.
ISSN
20900384
e-ISSN
20900392
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3205200898
Copyright
Copyright © 2025 Tuan Minh Vo et al. International Journal of Hypertension published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License (the “License”), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/