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© 2025. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

ABSTRACT

Background

The causal relationships between sleep traits and allergic diseases remain unclear. This study sought to explore their causal associations using Mendelian randomization (MR) analysis.

Methods

This study utilized summary‐level data from genome‐wide association studies (GWAS) and selected genetic variants associated with sleep traits as instrumental variables (IVs). For the primary analysis, the inverse‐variance weighted (IVW) method was utilized. To further evaluate causal effects, we applied weighted median, weighted mode, and MR‐Egger regression. Sensitivity analyses, such as linkage disequilibrium score (LDSC) regression, MR‐Egger regression, Cochran's Q test, leave‐one‐out analysis, and MR‐PRESSO, were carried out to confirm result robustness.

Results

IVW analysis revealed that genetically predicted insomnia was causally associated with a higher risk of atopic dermatitis (OR = 1.79, 95% CI: 1.17‐2.74, P = 0.01), and preferring an evening chronotype was causally associated with a lower risk of allergic rhinitis (IVW: OR = 0.99, 95% CI: 0.99‐1.00, P = 0.02). The LDSC analysis further identified a significant genetic correlation between insomnia and atopic dermatitis (rg = 0.107, P = 0.039), but not between chronotype and allergic rhinitis (rg = ‐0.036, P = 0.339). No significant connections were identified between other sleep traits and allergic diseases. The MR‐Egger intercept test did not indicate pleiotropy, except for the association with allergic asthma.

Conclusion

Chronotype and insomnia were causally associated with the efficacy of sleep‐based interventions in allergic disease management.

Details

Title
Insomnia Associated With Increased Risk of Atopic Dermatitis: A Two‐Sample Mendelian Randomization Study
Author
Ni, Xiuqin 1   VIAFID ORCID Logo  ; Li, Xing 2 ; Li, Jiaxin 1 

 Department of Basic Medicine, School of Health Sciences, Jiangsu Food & Pharmaceutical Science College, Huai'an, Jiangsu, China 
 Department of Neurology, Hongze District People's Hospital, Huai'an, Jiangsu, China 
Section
ORIGINAL ARTICLE
Publication year
2025
Publication date
May 1, 2025
Publisher
John Wiley & Sons, Inc.
e-ISSN
21623279
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3210269076
Copyright
© 2025. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.