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© 2025 He et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The incidence of Metabolic dysfunction-associated steatotic liver disease (MASLD) is rising annually. Dietary intervention is a cornerstone of MASLD management. Flavonoids, which have anti-inflammatory properties, are thought to benefit MASLD. Using data from the National Health and Nutrition Examination Survey (NHANES) from 2007–2010 and 2017–2018, we conducted a large cross-sectional study. Weighted Logistic regression, Restricted Cubic Spline (RCS) models, and Weighted Quantile Sum (WQS) regressions were used to explore the relationship between Total flavonoid and subclass (Flavones, Flavan-3-ols, Flavonols, Flavonones, Isoflavones, Anthocyanins) intake and MASLD. Participants in the higher tertiles of Total flavonoids intake had 31–34% lower odds of MASLD compared to the lowest tertile intake in the fully adjusted models (Tertile2: OR 0.69, 95%CI 0.55–0.86, P = 0.002, Tertile 3: OR 0.66, 95%CI 0.52–0.84, P < 0.001). Increased intakes of Flavan-3-ols (Tertile 2 in Model 2: OR 0.65, 95%CI 0.49–0.87, P = 0.01), Flavanones (Tertile 3 in Model 2: OR 0.70, 95%CI 0.53–0.91, P = 0.01), and Isoflavones (Tertile 3 in Model 2: OR 0.65, 95%CI 0.52–0.83, P < 0.001) were significantly associated with 30–35% decreased odds of having MASLD. The RCS revealed a significant non-linear dose-response relationship between Total flavonoid, flavonols and MASLD. The WQS model showed that Flavones and Isoflavones had the largest negative contributions to MASLD risk. Our study demontrated a negative correlation between Total flavonoids and their subclasses and risk of MASLD, highlighting the importance of increasing dietary flavonoid intake in the prevention and treatment of MASLD.

Details

Title
Associations of flavonoid intakes with metabolic dysfunction-associated steatotic liver disease in US adults
Author
Yuwei He Yu Chang Xiangliang Liu; Li, Yuguang; Ji, Wei; Wang, Zhenyu; Cui, Jiuwei  VIAFID ORCID Logo 
First page
e0322797
Section
Research Article
Publication year
2025
Publication date
May 2025
Publisher
Public Library of Science
e-ISSN
19326203
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3213835148
Copyright
© 2025 He et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.