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© 2025. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Introduction

A minor subset of CD4+ T cells, known as regulatory T cells (Tregs), makes up 1-4% of lymphocytes in circulation. These cells are responsible for regulating excessive immune responses, promoting immune tolerance, and suppressing anti-tumor immunity. This study aimed to investigate how the CD4/CD8 ratio influences treatment outcomes and survival rates in patients newly diagnosed with lymphoma. The research involved analyzing samples extracted from bone marrow aspirates.

Methods

Our study included individuals diagnosed with lymphoma at the Clinic of Hematology in University of Health Sciences Türkiye, İstanbul Training and Research Hospital from January 2010 to January 2021. These patients underwent flow cytometric analysis of bone marrow aspiration samples at the time of their initial diagnosis.

Results

In the statistical analysis performed to reveal the effect of CD4/CD8 ratio on the interim response to treatment, the ratio was found to be significantly higher in patients with a response of complete response “(CR)” compared to others (p=0.003). The statistical analysis performed to reveal the effect of the ratio on the end-of-treatment response found higher in patients with a CR response compared to others (p=0.008). CD4/CD8 ratio did not have a significant effect on survival.

Conclusion

According to the literature review, the increase in the ratio of non-Treg CD4+ cells, and the high CD4/CD8 ratio contributes positively to the response. It will shed light on new studies evaluating the effect of subtypes of CD4+ T cells on response and survival in lymphomas.

Details

Title
The Effect of Bone Marrow CD4/CD8 Ratio on Lymphoma Response and Survival: Single Center Experience
Author
Vahit Can Çavdar  VIAFID ORCID Logo  ; Sönmez, Derya  VIAFID ORCID Logo  ; Bağnu Orhan  VIAFID ORCID Logo  ; Serin, Huriye  VIAFID ORCID Logo  ; Osman Yokuş  VIAFID ORCID Logo  ; Serin, İstemi  VIAFID ORCID Logo 
Pages
81-87
Section
Original Investigation
Publication year
2025
Publication date
May 2025
Publisher
Galenos Publishing House
ISSN
13048503
e-ISSN
2148094X
Source type
Scholarly Journal
Language of publication
Turkish; English
ProQuest document ID
3214090747
Copyright
© 2025. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.