Abstract

Background

Therapeutic plasma exchange (TPE) has been used in immunological diseases, conditions of hyperviscosity, and the removal of protein-bound drugs and toxins. Although complications may be encountered, its use has been reported to offer some degree of safety and clinical improvement for dogs. This case report aimed to describe the feasibility and safety of TPE in dogs.

Case presentation

Five dogs with immune-mediated hemolytic anemia (IMHA) and/or canine visceral leishmaniasis (CVL) not responsive to immunosuppressive treatment underwent TPE by centrifugation. Physical, laboratory, and cardiovascular parameters were assessed pre- and post-TPE. Although one dog presented with angioedema and another dog presented with neurological signs (nystagmus) during the procedure, no other significant hemodynamic or hemostatic complications were observed, and both the physical and cardiovascular parameters remained stable post-TPE. Both angioedema and nystagmus were controlled at post-TPE. A tendency for a decrease in serum protein and ionic calcium was the main laboratory finding.

Conclusions

Centrifugation-based TPE is a safe and feasible therapy in dogs with IMHA and CVL. Attention should be given to hypocalcemia, the tendency toward hypoproteinemia, and secondary complications such as the occurrence of neurological signs.

Details

Title
Evaluation of the safety and feasibility of extracorporeal therapy: therapeutic plasma exchange in dogs - report of five cases
Author
Suellen Rodrigues Maia; Reiner Silveira de Moraes; Silvano Salgueiro Geraldes; Maria Gabriela Picelli de Azevedo; Amanda Garcia Stefaniszen; Márcio Antônio Batistela Moreira; Afonso, Angélica; Mogollón García, Henry David; Adriano Sakai Okamoto; Melchert, Alessandra; Gomes Lourenço, Maria Lúcia; Regina Kiomi Takahira; Ferreira de Souza, Fabiana; Giuffrida, Rogério; Priscylla Tatiana Chalfun Guimarães Okamoto
Pages
1-9
Section
Case Report
Publication year
2025
Publication date
2025
Publisher
BioMed Central
e-ISSN
17466148
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3216564249
Copyright
© 2025. This work is licensed under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.