Abstract

Background: Glioma is the most common primary brain tumor, but its therapeutic effect is not very ideal up to now. The point of this study was to recognize the potential gene involved in lower-grade glioma (LGG) and to promote the treatment and prognosis for LGG patients. Method: During the investigation, we first studied the differential expression and the survival analysis of GNG5 in patients with glioma, LGG, and GBM, respectively. Then, independent prognostic analysis, the clinical relevance characteristics and the differential expressed genes (DEGs) were also evaluated. In addition, Metascape and GSEA analyses were carried out to achieve potential mechanism. Co-expression and immune infiltration analysis were finally conducted. Results: The results indicated that GNG5 as an independent prognostic indicator was negatively associated with the overall survival of LGG patients. Metascape and GSEA analyses showed that GNG5 may participate in complement and coagulation cascades pathway. The co-expression analysis was concluded that GNG5 was positively correlated with the following factors: C4B, PLAU, C1R, C1QC, C4A, SERPINA1, C1QB, CFI, C3. Conclusions: This study demonstrated that the highly expression of GNG5 in LGG may lead to poor prognosis. Besides, our research also revealed that GNG5 may be a promising immune-related biomarker for LGG patients.

Details

Title
Expression and prognosis of GNG5 in lower-grade glioma using public database
Author
Tan, Xiaohui 1 ; Zhou, Huandi 2 ; Hou, Liubing 2 ; Li, Haonan 1 ; Liu, Junling 1 ; Li, Yuehong 3 ; Xue, Xiaoying 1   VIAFID ORCID Logo 

1  Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China 
2  Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China; Department of Central Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China 
3  Department of Pathology, The Second Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China 
Pages
1101-1116
Publication year
2022
Publication date
Jan 2022
Publisher
Taylor & Francis Ltd.
ISSN
2689-5293
e-ISSN
2689-5307
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1080/26895293.2022.2131636
ProQuest document ID
3222597586
Copyright
© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons  Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.