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© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background: Physical exercise intervention in cystic fibrosis (CF) is of recent interest; however, no specific method to detect improvements in body composition and cardiovascular performance after transplantation has been investigated. This study aims to verify the feasibility of an exercise prescription program in CF lung-transplanted patients compared to other solid organ transplanted recipients (OLT) in terms of cardio-respiratory and body composition performance. Methods: The two groups, trained with a moderate intensity program, were evaluated by body composition analysis and a cardiopulmonary test (CPET) and compared to healthy subjects (HS). Results: A total of 10 CF, 10 OLT, and 10 HS were included. BMI was significantly lower in the CF group with lower total and appendicular free fat mass (p = 0.01). The CF group also showed significantly lower functional and cardiovascular parameters in the CPET test (peak VO2, VOR/HR) compared to the OLT and HS groups, but similar ventilatory response (VE/VCO2 slope) to OLT. In the CF group, free fat mass and functional parameters (peak VO2 and VO2/HR) were negatively correlated (r = −0.51 and −0.52, respectively). Conclusions: CF patients would benefit from an individualized exercise prescription program to improve all cardiovascular parameters, overall body composition, and, consequently, related respiratory parameters. Peak VO2 and body composition should be largely used to plan exercise prescription program among transplanted CF.

Details

Title
Exercise Prescription in Lung-Transplanted Cystic Fibrosis Adults
Author
Orlandi, Melissa 1 ; Pinnarò, Maria Stella 1 ; Corsi, Marco 1   VIAFID ORCID Logo  ; Borchi Beatrice 2 ; Cavallo Annalisa 2 ; Guarducci, Sandra 2 ; Bartoloni Alessandro 2   VIAFID ORCID Logo  ; Donati Martina 3 ; Defraia Cecilia 3 ; Nesi Leonardo 3 ; Sparacio Stefano 3 ; Mannini, Claudia 4 ; Lavorini Federico 4 ; Bini Vittorio 5   VIAFID ORCID Logo  ; Bresci Silvia 2 ; Stefani, Laura 1   VIAFID ORCID Logo 

 Sports Medicine Centre, University of Florence, 50100 Florence, Italy; [email protected] (M.O.); [email protected] (M.S.P.); [email protected] (M.C.) 
 Cystic Fibrosis Centre, AOUC, 50100 Florence, Italy; [email protected] (B.B.); [email protected] (A.C.); [email protected] (S.G.); [email protected] (A.B.); [email protected] (S.B.) 
 Rehabilitation Service, AOUC, 50100 Florence, Italy; [email protected] (M.D.); [email protected] (C.D.); [email protected] (L.N.); [email protected] (S.S.) 
 Pneumology and Respiratory Physiology, AOU Careggi, 50100 Florence, Italy; [email protected] (C.M.); [email protected] (F.L.) 
 Medicine Department, University of Perugia, 06100 Perugia, Italy; [email protected] 
First page
212
Publication year
2025
Publication date
2025
Publisher
MDPI AG
e-ISSN
24115142
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3223913063
Copyright
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.