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© 2025 by the authors. Published by MDPI on behalf of the Lithuanian University of Health Sciences. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

(1) Background and Objectives: Endometriosis is defined as the presence of endometrial glands and stroma outside the uterine cavity. It affects 5–15% of women of reproductive age. Ovarian cancer develops in approximately 1% of patients with endometriosis. Prediction of those with endometriosis who will develop ovarian cancer is among the current research topics. (2) Materials and Methods: With this study, we aimed to reveal the role of miRNA 200b and miRNA 21 in endometriosis-associated ovarian carcinoma (EAOC). Thirteen patients diagnosed as having EAOC between 2015 and 2023 were included, with their endometriosis and eutopic endometrium tissues (Group 3: 13 patients, 39 tissue samples). Two separate groups were then detected to compare with these cases: Group 2 composed of tuba-ovarian endometriosis with its eutopic endometrium (10 patients, 20 tissue samples) and Group 1 composed of eutopic endometrium only (10 patients, 10 tissue samples). The foci marked on H&E sections were determined from the area on the relevant paraffin blocks and small tissue samples were taken in tubes to be studied with real-time PCR. (3) Results: No significant difference was detected for miRNA 21 and miRNA 200b expression levels among eutopic endometrium, endometriosis, and cancer foci in Group 3. However, miRNA 21 and miRNA 200b expression levels in the eutopic endometrial tissue of cases with ovarian cancer were significantly higher than in the eutopic endometrial tissues of cases with (Group 2) and without endometriosis (Group 1). (4) Conclusions: This study suggests that increased miRNA 200b and miRNA 21 expression levels detected in eutopic endometrial tissue of patients with endometriosis may contribute to identifying cases that may develop EAOC.

Details

Title
The Effect of MicroRNA 21 and MicroRNA 200b Expression on Carcinogenesis in Endometriosis-Associated Ovarian Cancers and Relationship with Clinicopathological Parameters
Author
Talu Esra Canan Kelten 1 ; Ulukuş, Emine Çağnur 2 ; Çakır Yasemin 3 ; Durak, Merih Güray 3   VIAFID ORCID Logo  ; Bayramoğlu Zeynep 3 ; Tunç, Timur Hikmet 4 ; Sefa, Kurt 4 ; Özdemir, Sefai Merve 5 ; Aktaş Safiye 6   VIAFID ORCID Logo 

 Department of Pathology, Tepecik Training and Research Hospital, Izmir Faculty of Medicine, University of Health Sciences, Izmir 35540, Türkiye, Department of Molecular Pathology, Faculty of Medicine, Institute of Health Sciences, DokuzEylul University, Izmir 35410, Türkiye 
 Department of Pathology, Memorial Ataşehir Hospital, Istanbul 34750, Türkiye; [email protected] 
 Department of Pathology, Faculty of Medicine, DokuzEylul University, Izmir 35340, Türkiye; [email protected] (Y.Ç.); 
 Department of Obstetrics and Gynaecology, Faculty of Medicine, DokuzEylul University, Izmir 35340, Türkiye 
 Department of Basic Oncology, Institute of Oncology, DokuzEylul University, Izmir 35330, Türkiye 
 Department of Molecular Pathology, Faculty of Medicine, Institute of Health Sciences, DokuzEylul University, Izmir 35410, Türkiye, Department of Pathology, Faculty of Medicine, DokuzEylul University, Izmir 35340, Türkiye; [email protected] (Y.Ç.); 
First page
1035
Publication year
2025
Publication date
2025
Publisher
MDPI AG
ISSN
1010660X
e-ISSN
16489144
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3223926286
Copyright
© 2025 by the authors. Published by MDPI on behalf of the Lithuanian University of Health Sciences. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.