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© 2025 by the authors. Published by MDPI on behalf of the Österreichische Pharmazeutische Gesellschaft. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Polychlorinated biphenyls (PCBs) are synthetic chemical compounds that have bioaccumulated and contaminated the entire global ecosystem, causing neurotoxic effects. However, polyphenols may have protective effects against this neurotoxicity. We aimed to investigate the neuroprotective effect of a hydroalcoholic extract of fresh leaves of Alpinia zerumbet (ALE), which is rich in polyphenols, on the neurobehavioral changes induced by 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126). We divided C57BL/6 male mice into four groups (n = 40): Control, Control + ALE, PCB, and PCB + ALE. We administered the ALE (50 mg/kg/day) through drinking water and PCB 126 (2 mg/kg/once a week) intraperitoneally for four weeks. The mice were subjected to the elevated plus maze (EPM) and open field (OF) tests in the last week of treatment. PCB 126 reduced locomotor activity, DOPAC levels, dopamine turnover, and D2 receptor expression. This compound also increased lipid peroxidation, tyrosine levels, and BAX expression in the cerebral cortex. Notably, ALE treatment prevented locomotor activity reduction and increased DOPAC levels, dopamine turnover, and D2 receptor expression. Moreover, the extract prevented the PCB-induced increases in BAX expression and lipid peroxidation. Finally, the ALE increased SOD antioxidant activity. Our investigation highlights that using the ALE may serve as a therapeutic strategy against PCB-induced neurotoxicity.

Details

Title
Alpinia zerumbet Extract Mitigates PCB 126-Induced Neurotoxicity and Locomotor Impairment in Adult Male Mice
Author
da Silva Paula Hosana Fernandes 1   VIAFID ORCID Logo  ; Fernandes, Jemima Isnardo 2 ; de Menezes Matheus Pontes 1 ; Fontes-Dantas, Fabrícia Lima 1   VIAFID ORCID Logo  ; Freitas André Luiz Nunes 2 ; Correa, Rayane Efraim 2   VIAFID ORCID Logo  ; de Araujo Ulisses Cesar 2 ; Ognibene, Dayane Teixeira 1   VIAFID ORCID Logo  ; da Costa Cristiane Aguiar 1   VIAFID ORCID Logo  ; Filgueiras Cláudio Carneiro 2   VIAFID ORCID Logo  ; Manhães, Alex Christian 2   VIAFID ORCID Logo  ; Beltrame, Daleprane Júlio 3   VIAFID ORCID Logo  ; de Castro, Resende Angela 1 ; de Bem Graziele Freitas 1   VIAFID ORCID Logo 

 Department of Pharmacology and Psychobiology, Roberto Alcantara Gomes Biology Institute (IBRAG), Rio de Janeiro State University (UERJ), Rio de Janeiro 20551-030, RJ, Brazil; [email protected] (P.H.F.d.S.); [email protected] (M.P.d.M.); [email protected] (F.L.F.-D.); [email protected] (D.T.O.); [email protected] (C.A.d.C.); [email protected] (A.d.C.R.) 
 Department of Physiology, Roberto Alcantara Gomes Biology Institute (IBRAG), Rio de Janeiro State University (UERJ), Rio de Janeiro 20551-030, RJ, Brazil; [email protected] (J.I.F.); [email protected] (A.L.N.F.); [email protected] (R.E.C.); [email protected] (U.C.d.A.); [email protected] (C.C.F.); [email protected] (A.C.M.) 
 Department of Basic Experimental Nutrition, Institute of Nutrition, Rio de Janeiro State University (UERJ), Rio de Janeiro 20551-030, RJ, Brazil; [email protected] 
First page
23
Publication year
2025
Publication date
2025
Publisher
MDPI AG
ISSN
00368709
e-ISSN
22180532
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3223940355
Copyright
© 2025 by the authors. Published by MDPI on behalf of the Österreichische Pharmazeutische Gesellschaft. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.