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© 2025. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

There is an urgent need to develop targeted heat‐alleviation strategies to protect heat‐vulnerable older adults. We have shown that electric fan use had nominal impact on reducing body core temperature and cardiovascular strain during daylong exposure to simulated indoor overheating. Here, we examined the effects of pedestal fan use during exposure to hot conditions on systemic markers of enterocyte damage, immune activation, renal ischemia, and inflammation in older adults. Eighteen adults (8 females; age 72, SD 7 years) underwent 3 randomized 8‐h exposures to 36°C, 45% relative humidity seated in front of a fan delivering air speeds of 0 m/s (control), 2 m/s (normal air speed delivered by electric fans), or 4 m/s (air speed used in biophysical modeling). Body core temperature and cardiovascular strain were measured throughout. Blood samples were obtained for analysis of systemic biomarkers before and at the end of exposure. End‐exposure core temperature was elevated ~1.0°C from baseline in all conditions. Following heat exposure, IFABP increased by 364 pg/mL [95% CI: 59, 670; p = 0.02] and LBP increased by 3.06 ng/mL [1.12, 5.00; p = 0.002] but was not different between the fan use and control condition (all p ≥ 0.15). No changes were observed for sCD14, IL‐6, TNFα, CRP, or NGAL (all p ≥ 0.15). The use of electric fans during daylong exposure to indoor overheating failed to meaningfully mitigate increases in physiological strain or biochemical markers associated with enterocyte damage and immune activation in older adults. ClinicalTrials.gov identifier: NCT05695079.

Details

Title
Effect of pedestal fan use on serum stress biomarkers in older adults exposed to simulated daylong indoor overheating
Author
Lee, Ben J. 1 ; McCarthy, Thomas 1 ; O'Connor, Fergus 2 ; Davey, Sarah L. 1 ; Thake, C. Douglas 1 ; McCormick, James J. 2 ; King, Kelli E. 2 ; Boulay, Pierre 3 ; Meade, Robert D. 4 ; Kenny, Glen P. 5   VIAFID ORCID Logo 

 Occupational and Environmental Physiology Group, Centre for Physical Activity, Sport, Exercise Sciences, Coventry University, Coventry, UK 
 Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada 
 Faculty of Physical Activity Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada 
 Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada, Department of Epidemiology, T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA 
 Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada 
Section
ORIGINAL ARTICLE
Publication year
2025
Publication date
Jun 1, 2025
Publisher
John Wiley & Sons, Inc.
e-ISSN
2051817X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3224481604
Copyright
© 2025. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.