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Abstract

Cardiac amyloidosis is a progressive infiltrative disease and an important cause of atrial arrhythmias, stroke and heart failure. Abnormal amyloid fibril deposition throughout the heart leads to a host of clinical manifestations and complications. Although atrial abnormalities are typically regarded as a consequence of ventricular diastolic dysfunction or atrial arrhythmias, there is emerging evidence that primary defects of atrial structure and function may be present. An atrial cardiomyopathy may be a sign of early cardiac disease, and an unrecognised independent marker of worse prognosis.

This review summarizes current evidence specifically for atrial cardiomyopathy in cardiac amyloidosis, with a focus on imaging and clinical outcomes.

Details

Title
Atrial cardiomyopathy in cardiac amyloidosis: clinical imaging and manifestations
Author
Gorrie, Natasha 1 ; Geenty, Paul 2 ; Rye, Eleanor 3 ; Sivasubramaniam, Vanathi 4 ; Carroll, Antonia 5 ; McCaughan, Georgia 6 ; Thomas, Liza 7 ; Fatkin, Diane 1 ; Bart, Nicole 1 

1  Victor Chang Cardiac Research Institute, Darlinghurst, Australia (GRID:grid.1057.3) (ISNI:0000 0000 9472 3971); St Vincent’s Hospital, Cardiology Department, Darlinghurst, Australia (GRID:grid.413105.2) (ISNI:0000 0000 8606 2560); UNSW, School of Clinical Medicine, Faculty of Medicine and Health, Kensington, Australia (GRID:grid.1005.4) (ISNI:0000 0004 4902 0432) 
2  Westmead Hospital, Department of Cardiology, Sydney, Australia (GRID:grid.413252.3) (ISNI:0000 0001 0180 6477); University of Sydney, Westmead Clinical School, Sydney, Australia (GRID:grid.1013.3) (ISNI:0000 0004 1936 834X) 
3  Victor Chang Cardiac Research Institute, Darlinghurst, Australia (GRID:grid.1057.3) (ISNI:0000 0000 9472 3971); St Vincent’s Hospital, Cardiology Department, Darlinghurst, Australia (GRID:grid.413105.2) (ISNI:0000 0000 8606 2560) 
4  UNSW, School of Clinical Medicine, Faculty of Medicine and Health, Kensington, Australia (GRID:grid.1005.4) (ISNI:0000 0004 4902 0432); St Vincent’s Hospital, Darlinghurst, Australia (GRID:grid.413105.2) (ISNI:0000 0000 8606 2560); SydPath, Darlinghurst, Australia (GRID:grid.413105.2) 
5  St Vincent’s Hospital, Darlinghurst, Australia (GRID:grid.413105.2) (ISNI:0000 0000 8606 2560); Sydney University, Faculty of Medicine and Health, Brain and Mind Centre, Camperdown, Australia (GRID:grid.1013.3) (ISNI:0000 0004 1936 834X) 
6  UNSW, School of Clinical Medicine, Faculty of Medicine and Health, Kensington, Australia (GRID:grid.1005.4) (ISNI:0000 0004 4902 0432); St Vincent’s Hospital, Darlinghurst, Australia (GRID:grid.413105.2) (ISNI:0000 0000 8606 2560); Garvan Institute of Medical Research, Darlinghurst, Australia (GRID:grid.415306.5) (ISNI:0000 0000 9983 6924) 
7  Westmead Hospital, Department of Cardiology, Sydney, Australia (GRID:grid.413252.3) (ISNI:0000 0001 0180 6477); University of Sydney, Westmead Clinical School, Sydney, Australia (GRID:grid.1013.3) (ISNI:0000 0004 1936 834X); University of NSW, School of Clinical Medicine, South West Clinical School, Sydney, Australia (GRID:grid.1005.4) (ISNI:0000 0004 4902 0432) 
Pages
8
Publication year
2025
Publication date
Dec 2025
Publisher
Nature Publishing Group
e-ISSN
29482836
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s44325-025-00043-z
ProQuest document ID
3225849424
Copyright
Copyright Nature Publishing Group Dec 2025