Kynurenic Acid Is a Predictive Prognostic Metabolic Marker in ST-Elevation Myocardial Infarction

Abstract

STEMI recognized as a metabolically influential disease is distinguished by substantial alterations in metabolic products. [...]exploring the novel therapeutic targets in STEMI patients has profound implications for the development of personalized medicine [5, 6]. Previous studies indicated an intriguing positive relationship between KYNA levels and adverse cardiovascular events related to atherosclerotic plaque instability and cardiovascular mortality [12]. [...]our study was designed to evaluate the predictive capacity of KYNA levels in a cohort of 973 STEMI patients, with a particular focus on elucidating its significance as a prognostic indicator. 2. Given that we would include five variables in our model, we required at least 50 MACEs. [...]we proposed a total sample size of 1000 STEMI patients. Continuous variables were presented as mean values±standard deviation or median values along with interquartile ranges (IQRs; Q1 and Q3) and compared by analysis of variance (ANOVA) or the nonparametric Kruskal–Wallis H test, contingent upon the data distribution.