儿童和青少年非酒精性脂肪性肝病与维生素D水平关系的Meta分析

Abstract

目的 系统评价儿童和青少年维生素D水平和非酒精性脂肪性肝病(NAFLD)的相关性。 方法 计算机检索PubMed、Cochrane Library、Embase数据库以及CNKI、中国生物医学文献数据库、万方和维普数据库，收集有关儿童及青少年维生素D水平与NAFLD之间关系的研究，检索时限从建库到2020年8月。按照纽卡斯尔-渥太华量表(NOS)进行文献质量评价，采用RevMan 5.3软件进行数据分析。 结果 Meta分析最终纳入10篇文献，NAFLD组共622例，健康对照组共1608例。10篇纳入研究的NOS评分均≥6分。10篇文献采用随机效应模型合并(I²=97%, P＜0.05)，NAFLD组血清25(OH)D水平显著低于对照组，差异有统计学意义(SMD=-1.40, 95%CI: -2.07~-0.72)。 结论 儿童和青少年NAFLD患者血清中25(OH)D水平显著降低，其可能与NAFLD的进展和严重程度有关。

Alternate abstract:

Objective To systematically evaluate the association between vitamin D level and nonalcoholic fatty liver disease (NAFLD) in children and adolescents. Methods Related English and Chinese databases, including PubMed, Cochrane Library, Embase, CNKI, CBM, Wanfang Data, and VIP, were searched for studies on the association between vitamin D level and NAFLD in children and adolescents published up to August 2020. Newcastle-Ottawa Scale (NOS) was used to evaluate quality of studies, and RevMan 5.3 software was used for data analysis. Results A total of 10 articles were included in the meta-analysis, with 622 patients in the NAFLD group and 1608 in the healthy control group. All 10 articles had an NOS score of ≥6. A pooled analysis of the 10 articles was performed using a random effects model (I²=97%, P < 0.05). The NAFLD group had a significantly lower serum 25(OH) D level than the healthy control group (standardized mean difference=-1.40, 95% confidence interval: -2.07 to -0.72). Conclusion There is a significant reduction in serum vitamin D level in children and adolescents with NAFLD, which may be associated with the progression and severity of NAFLD.