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Environ Health Prev Med (2011) 16:9096 DOI 10.1007/s12199-010-0169-7
REGULAR ARTICLE
BMI, waist circumference, and clustering of cardiovascular risk factors in Japanese adults
Machi Suka Yuichi Miwa Yoshiki Ono
Hiroyuki Yanagisawa
Received: 5 February 2010 / Accepted: 14 July 2010 / Published online: 11 August 2010 The Japanese Society for Hygiene 2010
AbstractObjective To examine whether the association between waist circumference (WC) and clustering of cardiovascular risk factors varies with obesity (BMI) status.
Methods Using the 2008 health examination data of a Japanese health service association, eligible 57,141 adults aged 2065 years without coronary heart disease or stroke, whose blood sample had been taken in the fasting state, were enrolled in the study. The participants were classied as being underweight (BMI \18.5), normal weight (BMI18.524.9), and overweight (BMI C25.0). Multiple logistic regression analysis was performed to calculate adjusted odds ratios (OR) for clustering of cardiovascular risk factors. Receiver operating characteristic analysis was performed to assess the ability of WC to discriminate subjects with and without a clustering of cardiovascular risk factors. Results Clustering of cardiovascular risk factors was found in 16.0% of men and 3.4% of women. The adjusted OR [95% condence intervals (CI)] per 5-cm increase in WC of the underweight, normal weight, and overweight groups was 1.57 (1.122.20), 1.55 (1.491.62), and 1.34(1.301.38), respectively, for men and 1.50 (0.842.69),1.53 (1.401.68), and 1.32 (1.231.41), respectively, for women. The area under curve (95% CI) of the under-weight, normal weight, and overweight groups was 0.68(0.590.77), 0.70 (0.690.71), and 0.62 (0.610.63),
respectively, for men and 0.70 (0.530.86), 0.75 (0.730.78), and 0.64 (0.610.68), respectively, for women. Conclusion High WC was associated with increased risk of clustering of cardiovascular risk factors independent of BMI. As well as the magnitude of the association, the ability of WC to discriminate subjects with and without a clustering of cardiovascular risk factors varied with obesity (BMI) status.
Keywords Waist circumference Body mass index
Cardiovascular risk factors Metabolic syndrome Japan
Introduction
The metabolic syndrome is characterized by a clustering of cardiovascular risk factors in one person, and those individuals with the metabolic syndrome are at increased risk of developing coronary heart disease and other arterio-sclerotic diseases. The metabolic syndrome has become increasingly common in Japan as well as in Western countries. Based on the results of...