Abstract

This study was carried out to evaluate in vivo protective role of aqueous extract of stem and leaves of Tinospora cordifolia (TC) on the toxic effects of lead on the hematological values. The lead-treated (5 mg/kg body weight, intraperitonially, once daily) male albino mice concurrently received either T. cordifolia stem or leaves extracts (400 mg/kg body weight, orally, once daily) for the duration of 30 days. The animals exposed to lead showed significant decrease in RBC and Hb level. Significant decline in WBC, DLC, and PCV was also noticed. Increase in MCV values displaying reciprocal relationship with RBC, PCV, and Hb values in lead-treated mice were also recorded. These influences of lead were prevented by concurrent daily administration of T. cordifolia stem and leaves extract. These results suggested that simultaneous supplementation of T. cordifolia protects against lead intoxication.

Details

Title
Beneficial effects of Tinospora cordifolia on blood profiles in male mice exposed to lead
Author
Sharma, V; Pandey, D
Pages
8-11
Publication year
2010
Publication date
Jan 2010
Publisher
Medknow Publications & Media Pvt. Ltd.
ISSN
09716580
e-ISSN
09765131
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
864715064
Copyright
Copyright Medknow Publications & Media Pvt Ltd Jan 2010