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Environ Health Prev Med (2011) 16:217223 DOI 10.1007/s12199-010-0189-3
REGULAR ARTICLE
Brachial-ankle pulse wave velocity is an independent predictor of incident hypertension in Japanese normotensive male subjects
Hiroki Satoh Yasuaki Saijo Reiko Kishi
Hiroyuki Tsutsui
Received: 8 May 2010 / Accepted: 19 October 2010 / Published online: 2 December 2010 The Japanese Society for Hygiene 2010
AbstractObjectives Cardiovascular morbidity and mortality are closely associated with hypertension, however, predictors of incident hypertension have not been fully established. We have conducted a study aimed at evaluating whether brachial-ankle pulse wave velocity (baPWV) is a predictor of incident hypertension.
Methods The relation between baPWV, a noninvasive index of aortic stiffness, and incident hypertension was evaluated in a cohort of 2,278 Japanese normotensive male subjects with a follow-up of 3 years.
Results Of the 2, 278 study participants, 151 (6.6%) had incident hypertension during the follow-up. After adjustment for variables, including age, gender, body mass index (BMI), smoking habit, alcohol consumption, diabetes mellitus, hyperlipidemia, family history of hypertension, heart rate, systolic blood pressure, low-density lipoprotein cholesterol, triglyceride, and fasting plasma glucose, multiple logistic regression analysis revealed that baPWV was a signicant and independent predictor of incident hypertension with an adjusted odds ratio 1.45 (95% condence
interval 1.171.79, P \ 0.01). In addition, baPWV values [1,380 cm/s indicated a high risk for incident hypertension.
Conclusions Among the Japanese normotensive male subjects participating in this study, BaPWV was a signi-cant and independent predictor of incident hypertension. This result suggests that BaPWV could be a useful screening method to identify normotensive individuals who should be targeted for interventions aimed at preventing the incident hypertension.
Keywords Arterial stiffness Hypertension Pulse
wave velocity Cohort studies Japanese male subjects
Introduction
The incidence and prevalence of hypertension increase with age. It has been well established that hypertension is associated with increased cardiovascular morbidity and mortality [15]. As such, it is of clinical importance to identify normotensive subjects who are at increased risk for developing hypertension and establish the conventional index that can be widely used in routine clinical practice. Previous studies have identied indices of central arterial stiffness assessed by ultrasound that could be used predict future hypertension in normotensive community population [6, 7]. Najjar et al. demonstrated that carotidfemoral pulse wave velocity (PWV), a non-invasive marker...