Abstract

Abstract

Background: Genome-wide linkage studies for Alzheimer's disease have implicated several chromosomal regions as potential loci for susceptibility genes.

Methods: In the present study, we have combined a selection of affected relative pairs (ARPs) from the UK and the USA included in a previous linkage study by Myers et al . (Am J Med Genet, 2002), with ARPs from Sweden and Washington University. In this total sample collection of 397 ARPs, we have analyzed linkage to chromosomes 1, 9, 10, 12, 19 and 21, implicated in the previous scan.

Results: The analysis revealed that linkage to chromosome 19q13 close to the APOE locus increased considerably as compared to the earlier scan. However, linkage to chromosome 10q21, which provided the strongest linkage in the previous scan could not be detected.

Conclusion: The present investigation provides yet further evidence that 19q13 is the only chromosomal region consistently linked to Alzheimer's disease.

Details

Title
Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs
Author
Blom, Elin S; Giedraitis, Vilmantas; Arepalli, Sampath; Hamshere, Marian L; Adighibe, Omanma; Goate, Alison; Williams, Julie; Lannfelt, Lars; Hardy, John; Vrièze, Fabienne Wavrant-De; Glaser, Anna
Pages
122
Publication year
2009
Publication date
2009
Publisher
BioMed Central
e-ISSN
14712350
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1471-2350-10-122
ProQuest document ID
902125133
Copyright
© 2009 Blom et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.