Abstract

Abstract: Apoptosis induced by DNA damage is an important mechanism of tumor suppression and it is significant also in cancer chemotherapy. Mammalian cells activate the pathways of p53 to induce apoptosis of cells harboring irreparable DNA damages. While p53 induces expression of various pro-apoptotic genes and directly participates in the disruption of mitochondrial membrane polarization, it also increases expression of the cell cycle inhibitor p21 that is a dominant inhibitor of caspase-activation and apoptosis. Here we discuss how Damaged-DNA Binding Protein-2 (DDB2) subdues the level of p21 in cells harboring irreparable DNA damage to support activation of the caspases. We speculate a model in which DDB2 detects and couples the presence of un-repaired DNA damages to the proteolysis of p21, leading to the induction of apoptosis.

Details

Title
Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage
Author
Bagchi, Srilata; Raychaudhuri, Pradip
First page
3
Publication year
2010
Publication date
2010
Publisher
BioMed Central
e-ISSN
17471028
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1747-1028-5-3
ProQuest document ID
902304415
Copyright
© 2010 Bagchi and Raychaudhuri; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.