Abstract

Abstract: This article reviews the anti-inflammatory relative and anti-infectious effects of Evodia rutaecarpa and its major bioactive components and the involvement of the nitric oxide synthases, cyclooxygenase, NADPH oxidase, nuclear factor kappa B, hypoxia-inducible factor 1 alpha, reactive oxygen species, prostaglandins, tumor necrosis factor, LIGHT, amyloid protein and orexigenic neuropeptides. Their potential applications for the treatment of endotoxaemia, obesity, diabetes, Alzheimer's disease and their uses as cardiovascular and gastrointestinal protective agents, analgesics, anti-oxidant, anti-atherosclerosis agents, dermatological agents and anti-infectious agents are highlighted. Stimulation of calcitonin gene-related peptide release may partially explain the analgesic, cardiovascular and gastrointestinal protective, anti-obese activities of Evodia rutaecarpa and its major bioactive components.

Details

Title
Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa (Wuzhuyu ) and its major bioactive components
Author
Liao, Jyh-Fei; Chiou, Wen-Fei; Shen, Yuh-Chiang; Wang, Guei-Jane; Chen, Chieh-Fu
First page
6
Publication year
2011
Publication date
2011
Publisher
BioMed Central
ISSN
17498546
e-ISSN
1749-8546
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1749-8546-6-6
ProQuest document ID
902314532
Copyright
© 2011 Liao et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.