Abstract

Abstract: While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes . Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem.

Details

Title
Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes
Author
Van de Velde, Sébastien; Carryn, Stéphane; Van Bambeke, Françoise; Hill, Colin; Tulkens, Paul M; Sleator, Roy D
First page
23
Publication year
2009
Publication date
2009
Publisher
BioMed Central
e-ISSN
1757-4749
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
902477094
Copyright
© 2009 Van de Velde et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.