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© 2011 Walash et al

Abstract

Abstract: A rapid, simple and sensitive synchronous specrtofluorimetric method has been developed for the simultaneous analysis of binary mixture of metoprolol (MTP) and felodipine (FDP). The method is based upon measurement of the synchronous fluorescence intensity of the two drugs at Δλ of 70 nm in aqueous solution. The different experimental parameters affecting the synchronous fluorescence intensities of the two drugs were carefully studied and optimized. The fluorescence intensity-concentration plots were rectilinear over the ranges of 0.5-10 μg/mL and 0.2-2 μg/mL for MTP and FDP, respectively. The limits of detection were 0.11 and 0.02 μg/mL and quantification limits were 0.32 and 0.06 μg/mL for MTP and FDP, respectively. The proposed method was successfully applied for the determination of the two compounds in their commercial tablets and the results obtained were favorably compared to those obtained with a comparison method.

Details

Title
Synchronous fluorescence spectrofluorimetric method for the simultaneous determination of metoprolol and felodipine in combined pharmaceutical preparation
Author
Walash, Mohamed I; Belal, Fathallah F; El-Enany, Nahed M; El-Maghrabey, Mahmoud H
First page
70
Publication year
2011
Publication date
2011
Publisher
Springer Nature B.V.
e-ISSN
1752153X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
905755836
Copyright
© 2011 Walash et al