Abstract

Abstract: Hyaluronic acid (HA) is a natural and linear polymer composed of repeating disaccharide units of β-1, 3-N -acetyl glucosamine and β-1, 4-glucuronic acid with a molecular weight up to 6 million Daltons. With excellent viscoelasticity, high moisture retention capacity, and high biocompatibility, HA finds a wide-range of applications in medicine, cosmetics, and nutraceuticals.

Traditionally HA was extracted from rooster combs, and now it is mainly produced via streptococcal fermentation. Recently the production of HA via recombinant systems has received increasing interest due to the avoidance of potential toxins. This work summarizes the research history and current commercial market of HA, and then deeply analyzes the current state of microbial production of HA by Streptococcus zooepidemicus and recombinant systems, and finally discusses the challenges facing microbial HA production and proposes several research outlines to meet the challenges.

Details

Title
Microbial production of hyaluronic acid: current state, challenges, and perspectives
Author
Liu, Long; Liu, Yanfeng; Li, Jianghua; Du, Guocheng; Chen, Jian
Pages
99
Publication year
2011
Publication date
2011
Publisher
BioMed Central
e-ISSN
14752859
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1475-2859-10-99
ProQuest document ID
910700500
Copyright
© 2011 Liu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.