Abstract

Meeting abstractsEMPTY Summary Duchene Muscular Dystrophy (DMD) is a lethal disease caused by ubiquitous lack of dystrophin, but the interaction with regional cardiac mechanical forces that may facilitate eventual expression of abnormal contractile function is unknown. [...] the disturbed sheet mechanics may reflect functional consequences of abnormal Ca2+ handling in vivo, which likely correlates with membrane calcium channel dysfunction that precedes eventual cardiac failure.

Details

Title
Regional expression of myocardial sheet dysfunction in dystrophin-deficient cardiomyopathy elucidated with diffusion tensor MRI and optical calcium mapping
Author
Cheng, Ya-Jian; Lang, Di; Caruthers, Shelton D; Lanza, Gregory; Efimov, Igor; Chen, Junjie; Wickline, Samuel A
First page
O31
Publication year
2012
Publication date
2012
Publisher
BioMed Central
ISSN
10976647
e-ISSN
1532429X
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1532-429X-14-S1-O31
ProQuest document ID
919044991
Copyright
© 2012 Cheng et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.